PF-562271 besylate

Description: PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Target: CDK, FAK, PYK2. Smiles: OS(=O)(=O)c1ccccc1.CN(c1ncccc1CNc1nc(Nc2ccc3NC(=O)Cc3c2)ncc1C(F)(F)F)S(C)(=O)=O. References: Bagi CM, et al. Cancer Biol Ther. 2009, 8(9), 856-865.