Zu "K05725" wurden 195 Artikel gefunden!
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Anti-Recombinant Phospho-FAK (Tyr397), clone 6H11
Artikelnummer: E-AN301150L.100
PTK2(protein tyrosine kinase 2) Homo sapiens This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine...
| Schlagworte: | Anti-PTK2, Anti-p125FAK, Anti-pp125FAK, Anti-Focal adhesion kinase 1, Anti-Protein-tyrosine kinase 2, Anti-Focal adhesion... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-Recombinant FAK, clone 5A11
Artikelnummer: E-AN301036L.100
PTK2(protein tyrosine kinase 2) Homo sapiens This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine...
| Schlagworte: | Anti-PTK2, Anti-p125FAK, Anti-pp125FAK, Anti-Focal adhesion kinase 1, Anti-Protein-tyrosine kinase 2, Anti-Focal adhesion... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-phospho-FAK (Tyr576/Tyr577) / Focal Adhesion Kinase...
Artikelnummer: NSJ-FY12572
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-FAK (Tyr576/Tyr577) antibody detects focal adhesion kinase 1 when phosphorylated at tyrosine residues 576 and 577. Focal adhesion kinase, encoded by the PTK2 gene, is a cytoplasmic tyrosine...
| Schlagworte: | Anti-phospho-PTK2, Anti-phospho-p125FAK, Anti-phospho-pp125FAK, Anti-phospho-Focal adhesion kinase 1,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
790,00 €
Anti-PTK2
Artikelnummer: ATA-HPA029671.100
Rabbit Polyclonal PTK2 Antibody against Human protein tyrosine kinase 2. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000022607: 96%,...
| Schlagworte: | Anti-FAK, Anti-FRNK, Anti-FADK 1, Anti-PPP1R71, Anti-p125FAK, Anti-pp125FAK, EC=2.7.10.2, Anti-Focal adhesion kinase 1,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 264,00 €
ZINC40099027
Artikelnummer: Cay42956-1
ZINC40099027 is an activator of focal adhesion kinase (FAK). It induces FAK autophosphorylation in Caco-2 colon adenocarcinoma cells when used at a concentration of 10 nM. ZINC40099027 (10 nM) increases migration in a wound healing assay using Caco-2 cells. It increases wound closure and decreases ulcer area in a...
| Schlagworte: | ZN27, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1-pyrrolidinecarboxamide |
| Anwendung: | FAK activator |
| CAS | 1211825-25-0 |
| MW: | 449.47 D |
ab 79,00 €
PF-573228
Artikelnummer: Cay14924-1
Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified...
| Schlagworte: | FAK Inhibitor II, Focal Adhesion Kinase Inhibitor II,... |
| Anwendung: | PTK2 inhibitor |
| CAS | 869288-64-2 |
| MW: | 491.5 D |
ab 49,00 €
Anti-FAK1 Rabbit (Clone RM472)
Artikelnummer: Cay42837-100
Focal adhesion kinase 1 (FAK1) is a non-receptor tyrosine kinase and adaptor protein. It is composed of an N-terminal FERM domain, a proline-rich region, a catalytic domain, two additional proline-rich regions, and a C-terminal focal adhesion-targeting (FAT) domain, which can also be autonomously expressed as...
| Schlagworte: | FADK1, Focal Adhesion Kinase 1, p125FAK, pp125FAK, Protein-Tyrosine Kinase 2, PTK2 |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
554,00 €
PF-431396
Artikelnummer: Cay17665-1
Proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are nonreceptor tyrosine kinases that constitute the focal adhesion kinase subfamily. PYK2 is expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts where it has a positive role in osteoclast maturation and bone resorption....
| Schlagworte: | N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methane... |
| Anwendung: | FAK / PYK2 inhibitor |
| CAS | 717906-29-1 |
| MW: | 506.5 D |
ab 49,00 €
CEP-37440
Artikelnummer: Cay21278-25
CEP-37440 is a dual inhibitor of focal adhesion kinase 1 (FAK1, IC50s = 2.0 and 80 nM for in vitro enzyme and cellular inhibition, respectively) and anaplastic lymphoma kinase (ALK, IC50s = 3.1 and 22 nM for in vitro enzyme and cellular inhibition, respectively). It blocks the proliferation of inflammatory and...
| Schlagworte: | 2-[[5-chloro-2-[[(6S)-6,7,8,9-tetrahydro-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-... |
| Anwendung: | FAK1 & ALK inhibitor |
| CAS | 1391712-60-9 |
| MW: | 580.1 D |
ab 54,00 €
GSK2256098
Artikelnummer: Cay22955-1
GSK2256098 is an inhibitor of focal adhesion kinase (FAK). It is selective for FAK, inhibiting only FAK greater than 50% in a panel of 261 kinases. GSK2256098 inhibits FAK autophosphorylation at tyrosine 397 (Y397) in OVCAR8 ovarian, U87MG glioblastoma, and A549 lung cancer cell lines (IC50s = 15, 8.5, and 12 nM,...
| Schlagworte: | 2-[[5-chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxy-benzamide |
| Anwendung: | PTK2 inhibitor |
| CAS | 1224887-10-8 |
| MW: | 414.9 D |
ab 52,00 €
PND1186
Artikelnummer: Cay17668-5
PND1186 is a potent reversible focal adhesion kinase (FAK) inhibitor with an IC50 value of 1.5 nM against the recombinant enzyme and 100 nM in breast carcinoma cells. It promotes 4T1 breast carcinoma and ID8 ovarian carcinoma cell apoptosis when grown in anchorage-independent 3D cultures but had limited efficacy in...
| Schlagworte: | SR 2516, VS-4718, 2-[[2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methyl-benzamide |
| Anwendung: | FAK inhibitor |
| CAS | 1061353-68-1 |
| MW: | 501.5 D |
ab 85,00 €
FAK Inhibitor 14
Artikelnummer: Cay14485-10
Focal adhesion kinases (FAK) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are over-expressed in many types of cancer. FAK inhibitor 14 is a direct inhibitor of FAK1 autophosphorylation, blocking...
| Schlagworte: | Focal Adhesion Kinase Inhibitor 14, NSC 667249, NSC 677249, Y15, 1,2,4,5-benzenetetramine, tetrahydrochloride |
| Anwendung: | FAK1 autophosphorylation inhibitor |
| CAS | 4506-66-5 |
| MW: | 284 D |
ab 73,00 €