PF-06882961

PF-06882961 is an agonist of the glucagon-like peptide 1 receptor (GLP-1R). It induces cAMP accumulation in CHO cells expressing the human receptor (EC50 = 0.71 nM). Oral administration of PF-06882961 enhances insulin secretion in a glucose tolerance test, and subcutaneous administration decreases food intake in cynomolgus monkeys.. SMILES: OC(C1=CC=C(N=C(CN2CCC(C3=CC=CC(OCC4=C(F)C=C(C#N)C=C4)=N3)CC2)N5C[C@@H]6CCO6)C5=C1)=O. InChi Code: InChI=1S/C31H30FN5O4/c32-25-14-20(16-33)4-5-23(25)19-41-30-3-1-2-26(35-30)21-8-11-36(12-9-21)18-29-34-27-7-6-22(31(38)39)15-28(27)37(29)17-24-10-13-40-24/h1-7,14-15,21,24H,8-13,17-19H2,(H,38,39)/t24-/m0/s1. InChi Key: HYBAKUMPISVZQP-DEOSSOPVSA-N