Pergolide (mesylate)

Pergolide is a potent dopamine D1 and D2 receptor agonist (Kis = 111 and 0.495 nM, respectively, for rat striatal receptors). It depresses dopaminergic firing in paralyzed rats (ED50 = 2-selective antagonist spiperone or the dopamine D1-selective antagonist SCH 23390 (Cay-15631). Pergolide (0.025 and 0.05 mg/kg) increases the volume threshold for inducing bladder contraction in a cynomolgus monkey model of Parkinson's disease induced by MPTP. It also reduces carrageenan-induced paw edema in adrenalectomized rats (ED50 = 0.4 mg/kg).Formal Name: 8beta-[(methylthio)methyl]-6-propyl-ergoline, monomethanesulfonate. CAS Number: 66104-23-2. Synonyms: LY127809, NSC 319773. Molecular Formula: C19H26N2S . CH3SO3H. Formula Weight: 410.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: [H][C@@]12[C@](C3=C4C(C2)=CNC4=CC=C3)([H])C[C@@H](CSC)CN1CCC.OS(C)(=O)=O. InChi Code: InChI=1S/C19H26N2S.CH4O3S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21,1-5(2,3)4/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3,1H3,(H,2,3,4)/t13-,16-,18-,/m1./s1. InChi Key: UWCVGPLTGZWHGS-ZORIOUSZSA-N.