OSS-128167

OSS-128167 is an inhibitor of sirtuin 6 (SIRT6, IC50 = 89 µM). It is selective for SIRT6 over SIRT1 and SIRT2 (IC50s = 1,578 and 751 µM, respectively). OSS-128167 increases acetylation of histone H3 lysine 9 (H3K9) and glucose uptake and decreases TNF-alpha release in BxPC-3 cells. In vivo, OSS-128167 (100 µg/animal, i.c.v.) prevents decreases in left hemisphere cerebral levels of IL-1beta, TNF-alpha, and IL-6 and neutrophil infiltration induced by bexarotene (Cay-11571) in a rat model of subarachnoid hemorrhage.Formal Name: 5-[[3-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy-benzoic acid. CAS Number: 887686-02-4. Molecular Formula: C19H14N2O6. Formula Weight: 366.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml. lambdamax: 216, 238, 279 nm. SMILES: OC(C1=CC(NC(C2=CC=CC(NC(C3=CC=CO3)=O)=C2)=O)=CC=C1O)=O. InChi Code: InChI=1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26). InChi Key: HTJWLEGCECXGSQ-UHFFFAOYSA-N.