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OSS_128167
Artikelnummer: TGM-T4328-100mg
Description: OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 µM), SIRT1(IC50=1578 µM) and SIRT2(IC50=751 µM). Target: HBV, Sirtuin. Smiles: OC(=O)c1cc(NC(=O)c2cccc(NC(=O)c3ccco3)c2)ccc1O. References: Parenti MD, et al. Discovery of novel and selective SIRT6 inhibitors. J Med Chem. 2014...
| Schlagworte: | SIRT6-IN-1 |
| Anwendung: | SIRT6 inhibitor |
| CAS | 887686-02-4 |
| MW: | 366.32 D |
ab 40,00 €
OSS-128167
Artikelnummer: Cay29052-1
OSS-128167 is an inhibitor of sirtuin 6 (SIRT6, IC50 = 89 µM). It is selective for SIRT6 over SIRT1 and SIRT2 (IC50s = 1,578 and 751 µM, respectively). OSS-128167 increases acetylation of histone H3 lysine 9 (H3K9) and glucose uptake and decreases TNF-alpha release in BxPC-3 cells. In vivo, OSS-128167 (100...
| Schlagworte: | 5-[[3-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy-benzoic acid |
| Anwendung: | SIRT6 inhibitor |
| CAS | 887686-02-4 |
| MW: | 366.3 D |
ab 44,00 €
