Omapatrilat

Omapatrilat is an orally bioavailable angiotensin-converting enzyme (ACE) and neprilysin (NEP) inhibitior (IC50s = 1.7 and 5.3 nM, respectively, for the human enzymes). It inhibits the pressor response induced by angiotensin I (Cay-24737) in normotensive rats (ED50 = 0.07 µmol/kg) and lowers mean arterial pressure (MAP) in sodium-depleted spontaneously hypertensive rats when administered at a dose of 30 µmol/kg. Omapatrilat lowers MAP in rats when co-administered with bradykinin (Cay-37408). It also increases tracheal plasma extravasation in a rat model of upper airway angioedema in a dose-dependent manner.Formal Name: (4S,7S,10aS)-octahydro-4-[[(2S)-2-mercapto-1-oxo-3-phenylpropyl]amino]-5-oxo-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid. CAS Number: 167305-00-2. Synonyms: BMS-186716. Molecular Formula: C19H24N2O4S2. Formula Weight: 408.5. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 30 mg/ml. SMILES: OC([C@H]1N2[C@](SCC[C@@H](C2=O)NC([C@@H](S)CC3=CC=CC=C3)=O)([H])CCC1)=OOC([C@H]1N2[C@](SCC[C@@H](C2=O)NC([C@@H](S)CC3=CC=CC=C3)=O)([H])CCC1)=O. InChi Code: InChI=1S/C19H24N2O4S2/c22-17(15(26)11-12-5-2-1-3-6-12)20-13-9-10-27-16-8-4-7-14(19(24)25)21(16)18(13)23/h1-3,5-6,13-16,26H,4,7-11H2,(H,20,22)(H,24,25)/t13-,14-,15-,16-/m0/s1. InChi Key: LVRLSYPNFFBYCZ-VGWMRTNUSA-N.