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Omapatrilat
Artikelnummer: TGM-T16385-100mg
Description: Omapatrilat is a metalloprotease ACE and NEP dual inhibitor (Ki: 0.64 and 0.45 nM, respectively). Target: RAAS. Smiles: [H][C@]12CCC[C@H](N1C(=O)[C@H](CCS2)NC(=O)[C@@H](S)Cc1ccccc1)C(O)=O. References: Fryer RM, et al. Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank...
| Schlagworte: | BMS-186716 |
| Anwendung: | Targets neprilysin [EC:3.4.24.11] (MME, CD10) |
| CAS | 167305-00-2 |
| MW: | 408.53 D |
ab 60,00 €
Omapatrilat
Artikelnummer: Cay31738-1
Omapatrilat is an orally bioavailable angiotensin-converting enzyme (ACE) and neprilysin (NEP) inhibitior (IC50s = 1.7 and 5.3 nM, respectively, for the human enzymes). It inhibits the pressor response induced by angiotensin I (Cay-24737) in normotensive rats (ED50 = 0.07 µmol/kg) and lowers mean arterial pressure...
| Schlagworte: | BMS-186716,... |
| Anwendung: | Neprilysin inhibitor, ACE inhibitor |
| CAS | 167305-00-2 |
| MW: | 408.5 D |
ab 61,00 €
