NUC-1031

NUC-1031 is a prodrug form of the anticancer nucleoside analog gemcitabine (Cay-11690). NUC-1031 is more lipophilic than gemcitabine and enters cells through passive diffusion. It inhibits the growth of L1210, CEM, MP-2, and BxPC-3 cancer cells in vitro (IC50 = 35, 30, 60, and 40 nM, respectively). NUC-1031 (0.076 mmol/kg) reduces tumor growth in Mia-PaCa-2 and BxPC-3 mouse xenograft models, which are partially responsive and resistant to gemcitabine, respectively.Formal Name: N-(2'-deoxy-2',2'-difluoro-P-phenyl-5'-cytidylyl)-L-alanine, phenylmethyl ester. CAS Number: 840506-29-8. Molecular Formula: C25H27F2N4O8P. Formula Weight: 580.5. Purity: >98% (mixture of diastereomers). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12 mg/mL, DMSO: 14 mg/mL, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL, Ethanol: 10 mg/mL. lambdamax: 245 nm. SMILES: O[C@H]1C(F)(F)[C@H](N2C(N=C(N)C=C2)=O)O[C@@H]1COP(N[C@@H](C)C(OCC3=CC=CC=C3)=O)(OC4=CC=CC=C4)=O. InChi Code: InChI=1S/C25H27F2N4O8P/c1-16(22(33)36-14-17-8-4-2-5-9-17)30-40(35,39-18-10-6-3-7-11-18)37-15-19-21(32)25(26,27)23(38-19)31-13-12-20(28)29-24(31)34/h2-13,16,19,21,23,32H,14-15H2,1H3,(H,30,35)(H2,28,29,34)/t16-,19+,21+,23+,40?/m0/s1. InChi Key: NHTKGYOMICWFQZ-KKQYNPQSSA-N.