Zu "K10807" wurden 43 Artikel gefunden!
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Human RRM1 (Ribonucleotide Reductase M1) ELISA Kit
Artikelnummer: ELK-ELK3959.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human RRM1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human RRM1. Next,...
| Schlagworte: | RR1, RRM1, EC=1.17.4.1, Ribonucleotide reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Mouse RRM1 (Ribonucleotide Reductase M1) ELISA Kit
Artikelnummer: ELK-ELK7025.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse RRM1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse RRM1. Next,...
| Schlagworte: | Rrm1, EC=1.17.4.1, Ribonucleotide reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
LY2334737
Artikelnummer: Cay37425-1
LY2334737 is a prodrug form of the nucleoside analog gemcitabine (Cay-11690, Cay-9003096). In vivo, LY2334737 (8 mg/kg) reduces tumor volume in an MDA321-LM2-4175 breast cancer mouse xenograft model and increases survival in an SKOV3 ovarian cancer mouse xenograft model.Formal Name:...
| Schlagworte: | 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-cytidine |
| Anwendung: | Gemcitabine prodrug form |
| CAS | 892128-60-8 |
| MW: | 389.4 D |
ab 35,00 €
Gemcitabine
Artikelnummer: Cay11690-10
Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031 (Cay-9003247) and gemcitabine elaidate (Cay-28303) and a prodrug form of gemcitabine di- and triphosphates. Gemcitabine is phosphorylated by intracellular kinases to the intermediate metabolite gemcitabine monophosphate (Cay-31726) and the...
| Schlagworte: | DDFC, LY 188011, NSC 613327, 2'-deoxy-2',2'-difluoro-cytidine |
| Anwendung: | Antiretroviral activity, Apoptosis inducer |
| CAS | 95058-81-4 |
| MW: | 263.2 D |
ab 68,00 €
Cladribine
Artikelnummer: Cay12085-10
Cladribine is a nucleoside analog of deoxyadenosine and prodrug form of 2-chlorodeoxyadenosine triphosphate (2-CdATP). It is triphosphorylated to Cd-ATP by the successive actions of deoxycytidine kinase, nucleoside monophosphate kinase, and nucleoside diphosphate kinase. Cladribine is cytotoxic to resting or...
| Schlagworte: | 2-Chlorodeoxyadenosine, Biodribin, Jk 6251, Leustatin, NSC 105014, RWJ 26251, 2-chloro-2'-deoxy-adenosine |
| Anwendung: | Nucleoside analog, Lymphocyte cytotoxic |
| CAS | 4291-63-8 |
| MW: | 285.7 D |
ab 30,00 €
Clofarabine
Artikelnummer: Cay14125-5
Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-alpha (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM). It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial...
| Schlagworte: | Clolar, Evoltra, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine |
| Anwendung: | Ribonucleotide reductase and DNA polymerase-alpha Inhibitor |
| CAS | 123318-82-1 |
| MW: | 303.7 D |
ab 52,00 €
2',2'-Difluoro-2'-deoxyuridine
Artikelnummer: Cay11689-5
2',2'-Difluoro-2'-deoxyuridine is an active metabolite of the anticancer nucleoside analog gemcitabine (Cay-11690). It is formed by deamination of gemcitabine by cytidine deaminase in the liver. 2',2'-Difluoro-2'-deoxyuridine is cytotoxic to HepG2 and A549 cancer cells (IC50s = 3.13 and 3.92 µM, respectively). It...
| Schlagworte: | dFdU, 2'-deoxy-2',2'-difluoro-uridine |
| Anwendung: | Gemcitabine active metabolite |
| CAS | 114248-23-6 |
| MW: | 264.2 D |
ab 66,00 €
Gemcitabine-13C,15N2 (hydrochloride)
Artikelnummer: Cay22560-1
Gemcitabine-13C,15N2 is intended for use as an internal standard for the quantification of gemcitabine (Cay-11690, Cay-9003096) by GC- or LC-MS. Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031 (Cay-9003247) and gemcitabine elaidate (Cay-28303) and a prodrug form of gemcitabine di- and...
| Schlagworte: | 2'-deoxy-2',2'-difluoro-cytidine-2-13C-1,3-15N2, monohydrochloride |
| Anwendung: | GC-MS, LC-MS, internal standard, apoptosis inducer, RRM1 inhibitor |
| CAS | 2757566-59-7 |
| MW: | 302.6 D |
ab 238,00 €
NUC-1031
Artikelnummer: Cay9003247-1
NUC-1031 is a prodrug form of the anticancer nucleoside analog gemcitabine (Cay-11690). NUC-1031 is more lipophilic than gemcitabine and enters cells through passive diffusion. It inhibits the growth of L1210, CEM, MP-2, and BxPC-3 cancer cells in vitro (IC50 = 35, 30, 60, and 40 nM, respectively). NUC-1031 (0.076...
| Schlagworte: | N-(2'-deoxy-2',2'-difluoro-P-phenyl-5'-cytidylyl)-L-alanine, phenylmethyl ester |
| Anwendung: | Gemcitabine prodrug |
| CAS | 840506-29-8 |
| MW: | 580.5 D |
ab 50,00 €
Gemcitabine Elaidate
Artikelnummer: Cay28303-1
Gemcitabine elaidate is a lipophilic prodrug form of the nucleoside analog gemcitabine (Cay-11690, Cay-9003096) that contains an elaidic acid (Cay-90250) moiety. Gemcitabine elaidate inhibits growth of gemcitabine-sensitive L1210/L5, BCLO, and A2780 cells (IC50s = 0.0033, 0.0042, and 0.0025 µM, respectively) but not...
| Schlagworte: | CP 4126, 2'-deoxy-2',2'-difluoro-cytidine, 5'-(9E)-9-octadecenoate |
| Anwendung: | Lipophilic gemcitabine prodrug, antineoplastic, antimetabolite |
| CAS | 210829-30-4 |
| MW: | 527.6 D |
ab 43,00 €
Anti-RRM1
Artikelnummer: ARG55465.100
Protein function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. [The UniProt Consortium]
| Schlagworte: | Anti-RR1, Anti-RRM1, EC=1.17.4.1, Anti-Ribonucleotide reductase large subunit, Anti-Ribonucleoside-diphosphate reductase... |
| Anwendung: | WB, ICC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
624,00 €
Anti-RRM1
Artikelnummer: A305-260A
Protein function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. [The UniProt Consortium]
| Schlagworte: | Anti-RR1, Anti-RRM1, EC=1.17.4.1, Anti-Ribonucleotide reductase large subunit, Anti-Ribonucleoside-diphosphate reductase... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 164,00 €