Zu "K10807" wurden 79 Artikel gefunden!
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Anti-RRM1 Monoclonal Antibody
Artikelnummer: E-AN200083P.100
This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes....
| Schlagworte: | RR1, RRM1, EC=1.17.4.1, Ribonucleotide reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1,... |
| Anwendung: | FCM, ICC/IF |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
389,00 €
Gemcitabine
Artikelnummer: Cay11690-10
Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031 (Cay-9003247) and gemcitabine elaidate (Cay-28303) and a prodrug form of gemcitabine di- and triphosphates. Gemcitabine is phosphorylated by intracellular kinases to the intermediate metabolite gemcitabine monophosphate (Cay-31726) and the...
| Schlagworte: | DDFC, LY 188011, NSC 613327, 2'-deoxy-2',2'-difluoro-cytidine |
| Anwendung: | Antiretroviral activity, Apoptosis inducer |
| CAS | 95058-81-4 |
| MW: | 263.2 D |
ab 64,00 €
Cladribine
Artikelnummer: Cay12085-10
Cladribine is a nucleoside analog of deoxyadenosine and prodrug form of 2-chlorodeoxyadenosine triphosphate (2-CdATP). It is triphosphorylated to Cd-ATP by the successive actions of deoxycytidine kinase, nucleoside monophosphate kinase, and nucleoside diphosphate kinase. Cladribine is cytotoxic to resting or...
| Schlagworte: | 2-Chlorodeoxyadenosine, Biodribin, Jk 6251, Leustatin, NSC 105014, RWJ 26251, 2-chloro-2'-deoxy-adenosine |
| Anwendung: | Nucleoside analog, lymphocyte cytotoxic |
| CAS | 4291-63-8 |
| MW: | 285.7 D |
ab 34,00 €
Clofarabine
Artikelnummer: Cay14125-5
Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-alpha (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM). It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial...
| Schlagworte: | Clolar, Evoltra, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine |
| Anwendung: | Ribonucleotide reductase and DNA polymerase-alpha Inhibitor |
| CAS | 123318-82-1 |
| MW: | 303.7 D |
ab 57,00 €
2',2'-Difluoro-2'-deoxyuridine
Artikelnummer: Cay11689-5
2',2'-Difluoro-2'-deoxyuridine is an active metabolite of the anticancer nucleoside analog gemcitabine (Cay-11690). It is formed by deamination of gemcitabine by cytidine deaminase in the liver. 2',2'-Difluoro-2'-deoxyuridine is cytotoxic to HepG2 and A549 cancer cells (IC50s = 3.13 and 3.92 µM, respectively). It...
| Schlagworte: | dFdU, 2'-deoxy-2',2'-difluoro-uridine |
| Anwendung: | Gemcitabine active metabolite |
| CAS | 114248-23-6 |
| MW: | 264.2 D |
ab 73,00 €
Gemcitabine-13C,15N2 (hydrochloride)
Artikelnummer: Cay22560-1
Gemcitabine-13C,15N2 is intended for use as an internal standard for the quantification of gemcitabine (Cay-11690, Cay-9003096) by GC- or LC-MS. Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031 (Cay-9003247) and gemcitabine elaidate (Cay-28303) and a prodrug form of gemcitabine di- and...
| Schlagworte: | 2'-deoxy-2',2'-difluoro-cytidine-2-13C-1,3-15N2, monohydrochloride |
| Anwendung: | GC-MS, LC-MS, internal standard, apoptosis inducer, RRM1 inhibitor |
| CAS | 2757566-59-7 |
| MW: | 302.6 D |
ab 265,00 €
NUC-1031
Artikelnummer: Cay9003247-1
NUC-1031 is a prodrug form of the anticancer nucleoside analog gemcitabine (Cay-11690). NUC-1031 is more lipophilic than gemcitabine and enters cells through passive diffusion. It inhibits the growth of L1210, CEM, MP-2, and BxPC-3 cancer cells in vitro (IC50 = 35, 30, 60, and 40 nM, respectively). NUC-1031 (0.076...
| Schlagworte: | N-(2'-deoxy-2',2'-difluoro-P-phenyl-5'-cytidylyl)-L-alanine, phenylmethyl ester |
| Anwendung: | Gemcitabine prodrug |
| CAS | 840506-29-8 |
| MW: | 580.5 D |
ab 56,00 €
Gemcitabine Elaidate
Artikelnummer: Cay28303-1
Gemcitabine elaidate is a lipophilic prodrug form of the nucleoside analog gemcitabine (Cay-11690, Cay-9003096) that contains an elaidic acid (Cay-90250) moiety. Gemcitabine elaidate inhibits growth of gemcitabine-sensitive L1210/L5, BCLO, and A2780 cells (IC50s = 0.0033, 0.0042, and 0.0025 µM, respectively) but not...
| Schlagworte: | CP 4126, 2'-deoxy-2',2'-difluoro-cytidine, 5'-(9E)-9-octadecenoate |
| Anwendung: | Lipophilic gemcitabine prodrug, antineoplastic, antimetabolite |
| CAS | 210829-30-4 |
| MW: | 527.6 D |
ab 49,00 €
Anti-RRM1
Artikelnummer: ARG55465.100
Protein function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. [The UniProt Consortium]
| Schlagworte: | Anti-RR1, Anti-RRM1, EC=1.17.4.1, Anti-Ribonucleotide reductase large subunit, Anti-Ribonucleoside-diphosphate reductase... |
| Anwendung: | WB, ICC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
723,00 €
Anti-RRM1
Artikelnummer: A305-260A
Protein function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. [The UniProt Consortium]
| Schlagworte: | Anti-RR1, Anti-RRM1, EC=1.17.4.1, Anti-Ribonucleotide reductase large subunit, Anti-Ribonucleoside-diphosphate reductase... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 165,00 €
Human RRM1 / Ribonucleoside-diphosphate reductase large...
Artikelnummer: G-HUFI00543.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Anti-RRM1
Artikelnummer: E-AB-14316.120
This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important...
| Schlagworte: | Anti-RR1, Anti-RRM1, EC=1.17.4.1, Anti-Ribonucleotide reductase large subunit, Anti-Ribonucleoside-diphosphate reductase... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 89,00 €