NS 11021

NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa/KCa1.1). It is selective for BKCa and is thought to bind directly the alpha subunit. NS 11021 has been shown to relax intracavernous arterial rings and corpus cavernosum strips in vitro and to enhance erectile responses in intact rats.Formal Name: N'-[3,5-bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-thiourea. CAS Number: 956014-19-0. Molecular Formula: C16H9BrF6N6S. Formula Weight: 511.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/mL, DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL, DMSO: 10 mg/mL, Ethanol: 0.3 mg/mL. lambdamax: 243, 288 nm. SMILES: S=C(NC1=C(C2=NN=NN2)C=C(Br)C=C1)NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3. InChi Code: InChI=1S/C16H9BrF6N6S/c17-9-1-2-12(11(6-9)13-26-28-29-27-13)25-14(30)24-10-4-7(15(18,19)20)3-8(5-10)16(21,22)23/h1-6H,(H2,24,25,30)(H,26,27,28,29). InChi Key: MDKAFDIKYQMOMF-UHFFFAOYSA-N.