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Zu "K04936" wurden 24 Artikel gefunden!
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Artikelnummer: Cay11347-1
Penitrem A is a tremorgenic fungal toxin that acts as an inhibitor of large-conductance calcium-activated potassium channels KCa1.1/BK, inhibiting the binding of charybdotoxin with an IC50 value of 1.7 µM. It is currently used to evaluate the role of KCa1.1-mediated potassium flux in various cell processes and...
Schlagworte: | NSC 354845, Tremortin A,... |
Anwendung: | BKCa inhibitor |
CAS | 12627-35-9 |
MW: | 634.2 D |
ab 56,00 €
Artikelnummer: Cay11345-5
Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa) channels, as shown in patch clamp (Ki = 1.9 nM) and whole smooth muscle cell studies (Ki = 35.7 nM). It also enhances the binding of charybdotoxin (Cay-24115), a peptidyl neurotoxin, to BKCa...
Schlagworte: | 5,6,6a,7,12,12bS,12cR,13,14,14aS-decahydro-4bS-hydroxy-2R-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-1-benzopyrano[5',6... |
Anwendung: | BKCa channel inhibitor |
CAS | 57186-25-1 |
MW: | 435.6 D |
ab 61,00 €
Artikelnummer: Cay11351-1
Verruculogen is a tremorgenic mycotoxin isolated from species of Penicillium, Aspergillus, and other fungi. It selectively inhibits the activation of large-conductance calcium-activated potassium channels (KCa1.1/BK) potassium channels by charybdotoxin with a K1/2 value of 170 nM. Verruculogen also promotes the...
Schlagworte: | NA 209A, TR 1,... |
Anwendung: | Inhibitor of BK channel activation by charybdotoxin |
CAS | 12771-72-1 |
MW: | 511.6 D |
ab 134,00 €
Artikelnummer: Cay15347-1
NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa/KCa1.1). It is selective for BKCa and is thought to bind directly the alpha subunit. NS 11021 has been shown to relax intracavernous arterial rings and corpus cavernosum strips in vitro and to enhance erectile responses in intact...
Schlagworte: | N'-[3,5-bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-thiourea |
Anwendung: | KCNMA1 activator |
CAS | 956014-19-0 |
MW: | 511.2 D |
ab 43,00 €
Artikelnummer: Cay18876-10
NS 1619 is a calcium-dependent activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels in vascular smooth muscle. It is typically used at a concentration of 30 µM to hyperpolarize the membrane potential of single myocytes during studies of smooth muscle relaxation and vasodilation. Studies...
Schlagworte: | 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one |
Anwendung: | BKCa channel agonist |
CAS | 153587-01-0 |
MW: | 362.2 D |
ab 50,00 €
Artikelnummer: Cay29378-1
BMS 204352 is an activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels that increases KCa1.1 currents in X. laevis oocytes expressing human KCa1.1 in a calcium- and concentration-dependent manner. It decreases electrically induced population excitatory postsynaptic potentials (pEPSPs) in...
Schlagworte: | (+)-BMS 204352, (3S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one |
Anwendung: | BKCa channel activator |
CAS | 187523-35-9 |
MW: | 359.7 D |
ab 50,00 €
Artikelnummer: A303-409A
Protein function: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the...
Schlagworte: | Anti-hSlo, Anti-Slo1, Anti-KCNMA, Anti-MaxiK, Anti-KCNMA1, Anti-KCa1.1, Anti-Slo-alpha, Anti-BK channel, Anti-BKCA alpha,... |
Anwendung: | WB, IP |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: Cay14608-100
Iberiotoxin, a peptide purified from venom of the scorpion B. tamulus, is a selective blocker of large-conductance calcium-activated potassium channels (KCa1.1/BKCa). In single channel recordings, iberiotoxin can reversibly block outward currents mediated by KCa1.1 in excised membrane patches from bovine aortic...
Schlagworte: | 4-L-aspartic acid-6-L-aspartic acid-8-L-serine-9-L-valine-18-L-lysine-19-L-aspartic... |
Anwendung: | BKCa blocker |
CAS | 182897-30-9 |
MW: | 4230.9 D |
448,00 €
Artikelnummer: 200-301-G15
Anti-Mslo maxi- K channel Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Mslo from Mouse, Human, Rat, and Zebrafish based on 100% homology with the immunizing sequence. Cross-reactivity with Mslo from other sources has not been determined. Ion Channels...
Schlagworte: | Anti-mSlo, Anti-Slo1, Anti-Kcnma, Anti-mSlo1, Anti-MaxiK, Anti-Kcnma1, Anti-KCa1.1, Anti-Slo-alpha, Anti-BKCA alpha,... |
Anwendung: | IHC, IFM, IP, WB |
Wirt: | Mouse |
Spezies-Reaktivität: | mouse, human, rat, zebrafish |
698,00 €
Artikelnummer: NSJ-R31640
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Calcium-activated potassium channel subunit alpha-1 also known as KCa1.1, BK channel and Maxi K, is a voltage gated potassium channel encoded by the KCNMA1 gene and characterized by its large conductance of potassium ions (K+) through cell membranes. This gene...
Schlagworte: | Anti-Slo1, Anti-hSlo, Anti-MaxiK, Anti-KCNMA, Anti-KCa1.1, Anti-KCNMA1, Anti-Slo-alpha, Anti-BKCA alpha, Anti-BK channel,... |
Anwendung: | WB, IHC (paraffin) |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Artikelnummer: BVT-0443-M001
White to off-white solid. Soluble in DMSO, 100% ethanol, methanol or dichloromethane. Fumitremorgin-type alkaloid, Tremorgenic neurotoxic mycotoxin, Selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK, maxi-K) channels, Decreases GABA levels in CNS, Increases spontaneous glutamate and aspartate...
Schlagworte: | NA 209A, TR 1 |
Anwendung: | Selective KCNMA1 / KCa1.1 / BK channel blocker |
CAS | 12771-72-1 |
MW: | 511,6 D |
120,00 €
Artikelnummer: AG-CN2-0167-M001
Off-white solid. Soluble in DMSO, methanol or ethanol. Tremorgenic, Potent, selective and reversible inhibitor of high-conductance calcium-activated potassium (BKCa) channels, Reversible inhibitor of inositol 1,4,5-trisphosphate receptor (InsP(3)), Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor, Liver X...
Schlagworte: | BRN 5317894, NSC 658707 |
Anwendung: | High-conductance calcium-activated potassium (BKCa) channel inhibitor, SERCA inhibitor |
CAS | 57186-25-1 |
MW: | 435,6 D |
ab 50,00 €