Naratriptan (hydrochloride)

Naratriptan is a potent agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.4 and 1.5 nM, respectively, in a radioligand binding assay using human recombinant receptors). It is selective for 5-HT1B and 5-HT1D, lacking activity in rat aorta, guinea pig colon, and pig vena cava, that highly express 5-HT2A, 5-HT4, and 5-HT7 receptors, respectively, at concentrations up to 10 µM. Naratriptan induces contraction of isolated human coronary arteries (EC50 = 170 nM). In vivo, naratriptan (1-300 µg/kg) induces dose-dependent vasoconstriction of the carotid vascular bed in dogs. It also inhibits plasma protein extravasation induced by electrical stimulation of the trigeminal ganglion in the dura of anesthetized rats. Formulations containing naratriptan have been used in the treatment of migraine headaches.Formal Name: N-methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide, monohydrochloride. CAS Number: 143388-64-1. Molecular Formula: C17H25N3O2S . HCl. Formula Weight: 371.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble, Water: Slightly Soluble. SMILES: O=S(CCC1=CC=C2C(C(C3CCN(C)CC3)=CN2)=C1)(NC)=O.Cl. InChi Code: InChI=1S/C17H25N3O2S.ClH/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14,/h3-4,11-12,14,18-19H,5-10H2,1-2H3,1H. InChi Key: AWEZYKMQFAUBTD-UHFFFAOYSA-N.