Zu "K04153" wurden 241 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Donitriptan (hydrochloride)
Artikelnummer: Cay44116-1
Donitriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D. It inhibits forskolin-induced cAMP formation in C6 cells expressing the human receptors (pD2 = 8.91 and 9.57, respectively). Donitriptan is selective for 5-HT1B and 5-HT1D (Kis = 0.36 and 0.15 nM, respectively, for the human...
| Schlagworte: | F 11356, 4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]-1-piperazinyl]-benzonitrile, monohydrochloride |
| Anwendung: | 5-HT1B / 5-HT1D agonist |
| CAS | 170911-68-9 |
| MW: | 439,94 D |
ab 54,00 €
CHO-K1/5-HT1A/Galpha15 Stable Cell Line
Artikelnummer: GSC-M00330
The 5-Hydroxytryptamine receptor 1A (5-HT1A) is Gi-coupled GPCRs expressed in the cerebral cortex, hippocampus, septum, amygdala, and raphe nucelus, with lesser amounts in the basal ganglia and thalamus. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory...
| Schlagworte: | G-21, HTR1A, Serotonin receptor 1A, 5-hydroxytryptamine receptor 1A |
11.424,00 €
Serotonin (hydrochloride)
Artikelnummer: Cay14332-50
Serotonin is a monoamine neurotransmitter that is biochemically derived from tryptophan and produced in serotonergic neurons in the central nervous system and in enterochromaffin cells in the gastrointestinal tract. Serotonin is important in the regulation of mood, sleep, vomiting, sexuality, and appetite. Low...
| Schlagworte: | 5-HT, 5-Hydroxytryptamine, 3-(2-aminoethyl)-1H-indol-5-ol, monohydrochloride |
| Anwendung: | Monoamine neurotransmitter |
| CAS | 153-98-0 |
| MW: | 212.7 D |
ab 75,00 €
GR46611
Artikelnummer: Cay42235-1
A 5-HT1D agonist, induces cAMP accumulation in CHO cells expressing the human receptor at 10 µM, binds to 5-HT1A and 5-HT1B receptors (Kis = 1.3 and 0.2 nM, respectively)induces hypothermia and decreases hypothalamus and prefrontal cortex levels of 5-HIAA in guinea pigs at 50 µmol/kg, potentiates buspirone- or...
| Schlagworte: | 3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]-2-propenamide |
| Anwendung: | 5-HT1D agonist |
| CAS | 185259-85-2 |
| MW: | 377.5 D |
ab 38,00 €
Buspirone (hydrochloride) (CRM)
Artikelnummer: Cay42588-1
Buspirone (hydrochloride) (CRM) (Cay-42588) is a certified reference material categorized as an anxiolytic. Formulations containing buspirone have been used in the treatment of generalized anxiety disorder. This product is intended for research and forensic applications.
| Schlagworte: | 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione, monohydrochloride |
| Anwendung: | Certified reference material, anxiolytic |
| CAS | 33386-08-2 |
| MW: | 421.96 D |
107,00 €
Brexpiprazole
Artikelnummer: Cay22906-10
Brexpiprazole is a serotonin (5-HT) and dopamine receptor modulator that has high affinity (Ki = 1A and 5-HT2A serotonin, dopamine D2L, and alpha1B-, and alpha2C-adrenergic receptors in CHO cell membranes expressing the human receptors. It acts as a partial agonist of 5-HT1A, D2L, and D3 receptors (EC50s = 0.49,...
| Schlagworte: | OPC 34712, 7-[4-(4-benzo[b]thien-4-yl-1-piperazinyl)butoxy]-2(1H)-quinolinone |
| Anwendung: | 5-HT1A-receptor agonist |
| CAS | 913611-97-9 |
| MW: | 433.6 D |
ab 67,00 €
Dihydroergotamine (mesylate)
Artikelnummer: Cay23847-25
Dihydroergotamine is a derivative of ergotamine and an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (Kis = 0.3 and 2.5 nM, respectively, for human receptors). It binds to dopamine D2 and D3 as well as 5-HT2A receptors (K0.5s = 5, 16, and 38 nM, respectively) but has lower affinity for D1,...
| Schlagworte: | (+)-Dihydroergotamine, (5'alpha,10alpha)-9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-ergotaman-3',6',18-trione,... |
| Anwendung: | alpha1-Adrenergic receptor & serotonin receptor agonist/antagonist, dopamine D2 receptor agonist |
| CAS | 6190-39-2 |
| MW: | 679.8 D |
ab 56,00 €
Flibanserin
Artikelnummer: LKT-F4532.100
Flibanserin is an agonist at 5-HT1A receptors and an antagonist at 5-HT2A receptors. Flibanserin is clinically used to treat hypoactive sexual disorder in females. Flibanserin also decreases dystonia induced by L-DOPA and quinelorane in animal models of Parkinson's disease.
| Anwendung: | 5-HT1A-receptor agonist, 5-HT2-receptor antagonist |
| CAS | 167933-07-5 |
| MW: | 390.4 D |
ab 109,00 €
WAY-100635 (maleate)
Artikelnummer: Cay14599-5
WAY-100635 is a potent, silent antagonist of serotonin 5-HT1A receptors with an IC50 value of 2.2 nM (Ki = 0.8 nM) for inhibiting 5-HT1A receptors in rat hippocampal membranes. Because it displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes, WAY-100635 is classically used to examine the distribution and...
| Schlagworte: | N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide, 2Z-butenedioate |
| Anwendung: | 5-HT1A receptor antagonist |
| CAS | 1092679-51-0 |
| MW: | 538.6 D |
ab 122,00 €
Zolmitriptan
Artikelnummer: Cay15871-25
Zolmitriptan is a triptan that acts as an agonist of the serotonin (5-HT, Cay-14332) receptors 5-HT1B and 5-HT1D (Kis = 2.2 and 0.92 nM, respectively). Through this action, zolmitriptan inhibits cAMP formation in blood vessels, resulting in vessel constriction. Triptans, including zolmitriptan, are considered...
| Schlagworte: | BW 311C90, Zomig(R), 4S-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone |
| Anwendung: | 5-HT1B / 5-HT1D receptor agonist |
| CAS | 139264-17-8 |
| MW: | 287.4 D |
ab 85,00 €
Vortioxetine
Artikelnummer: Cay30183-5
Vortioxetine is a multimodal serotonergic agent that acts as a serotonin (5-HT, Cay-14332) reuptake inhibitor (Ki = 1.6 nM) and binds to the 5-HT1A, 5-HT1B, 5-HT3A, and 5-HT7 receptors (Kis = 15, 33, 3.7, and 19 nM, respectively). It also binds to the beta1-adrenergic receptor (Ki = 46 nM). It acts as an antagonist...
| Schlagworte: | 1-[2-[(2,4-dimethylphenyl)thio]phenyl]-piperazine |
| Anwendung: | Serotonin receptor antagonist |
| CAS | 508233-74-7 |
| MW: | 298.4 D |
ab 56,00 €
Vortioxetine
Artikelnummer: LKT-V5870.10
Vortioxetine exhibits neuromodulatory, antidepressant, anxiolytic, and cognition enhancing activities. Vortioxetine modulates serotonin levels in the brain by inhibiting the serotonin transporter (SERT) and 5-HT3A/7 receptors, acting as a partial agonist at the 5-HT1B receptor, and acting as a full agonist at the...
| Anwendung: | 5-HT3-receptor antagonist, 5-HT7-receptor antagonist, 5-HT1A-receptor agonist |
| CAS | 508233-74-7 |
| MW: | 298.45 D |
ab 94,00 €