N-Nonyldeoxynojirimycin

N-Nonyldeoxynojirimycin (NN-DNJ) is an inhibitor of acid alpha-glucosidase and alpha-1,6-glucosidase (IC50s = 0.42 and 8.4 µM, respectively). NN-DNJ (250 mg/kg per day) increases hepatic glycogen levels in fasted mice and gastrocnemius muscle glycogen levels in both fasted and fed mice. It is a chemical chaperone of beta-glucosidase that increases activity by 1.65-fold in patient-derived fibroblasts homozygous for the N370S Gaucher disease mutation when added to the culture medium at a concentration of 5 µM, but inhibits beta-glucosidase activity at concentrations greater than 60 µM. NN-DNJ inhibits viral replication in BHK-21 cells infected with Japanese encephalitis virus (JEV) or dengue virus serotype 2 (DEN-2) and has protective effects in a mouse model of lethal JEV challenge when administered at a dose of 200 mg/kg per day.Formal Name: (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol. CAS Number: 81117-35-3. Synonyms: NN-DNJ, Nonyl-DNJ. Molecular Formula: C15H31NO4. Formula Weight: 289.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: :, DMSO: slightly soluble, Methanol: slightly soluble. SMILES: OC[C@H]1N(CCCCCCCCC)C[C@H](O)[C@@H](O)[C@@H]1O. InChi Code: InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1. InChi Key: FTSCEGKYKXESFF-LXTVHRRPSA-N.