MSDC-0160

MSDC-0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. It inactivates the mitochondrial pyruvate carrier (MPC, IC50 = 1.2 µM) without affecting peroxisome proliferator-activated receptor gamma (PPARgamma, IC50 = 31.65 µM) in vitro. MSDC-0160 enhances the rate of insulin-stimulated lipogenesis in 3T3-L1 adipocytes in a dose-dependent manner. Dietary administration of MSDC-0160 (100 mg/kg) lowers blood glucose levels in obese, hyperglycemic, hyperinsulinemic, and insulin-resistant KKAgamma mice. MSDC-0160 prevents neurodegeneration in a C. elegans model of Parkinson's disease, an effect that is blocked by knockdown of the mammalian target of rapamycin (mTOR). It also prevents overactivation of mTOR in the MPTP-induced and engrailed heterozygous (En+/-) mouse models of Parkinson's disease.Formal Name: 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione. CAS Number: 146062-49-9. Molecular Formula: C19H18N2O4S. Formula Weight: 370.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 231, 273 nm. SMILES: CCc1ccc(nc1)C(=O)COc1ccc(cc1)CC1SC(=O)NC1=O. InChi Code: InChI=1S/C19H18N2O4S/c1-2-12-5-8-15(20-10-12)16(22)11-25-14-6-3-13(4-7-14)9-17-18(23)21-19(24)26-17/h3-8,10,17H,2,9,11H2,1H3,(H,21,23,24). InChi Key: IRNJSRAGRIZIHD-UHFFFAOYSA-N.