MSA-2

MSA-2 is an agonist of stimulator of interferon genes (STING). It binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 µM, respectively) and induces secretion of IFN-beta from THP-1 cells by 129% relative to induction by 2'3'-cGAMP (Cay-19887) when used at a concentration of 30 µM. MSA-2 reduces tumor growth in an MC-38 syngeneic mouse model of colon carcinoma in a dose-dependent manner and induces tumor regression when administered intratumorally or subcutaneously at doses of 450 µg and 50 mg/kg, respectively. It also acts synergistically with an anti-PD-1 antibody in MC-38, CT26, B16/F10, and LL/2 syngeneic mouse models.CAS Number: 129425-81-6. Synonyms: 5,6-dimethoxy-gamma-oxo-benzo[b]thiophene-2-Butanoic Acid. Molecular Formula: C14H14O5S. Formula Weight: 294.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 1 mg/ml. lambdamax: 213, 238, 324 nm. SMILES: COC1=C(OC)C=C(C=C(C(CCC(O)=O)=O)S2)C2=C1. InChi Code: InChI=1S/C14H14O5S/c1-18-10-5-8-6-13(9(15)3-4-14(16)17)20-12(8)7-11(10)19-2/h5-7H,3-4H2,1-2H3,(H,16,17). InChi Key: APCLRHPWFCQIMG-UHFFFAOYSA-N.