MRT10

MRT10 is an antagonist of the Smoothened (Smo) receptor with an IC50 value of 0.64 µM in a luciferase reporter assay. It also inhibits bodipy-cyclopamine binding to the murine Smo receptor (IC50 = 0.5 µM) when expressed in HEK293 cells.Formal Name: N-[[[3-(benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-trimethoxy-benzamide. CAS Number: 330829-30-6. Molecular Formula: C24H23N3O5S. Formula Weight: 465.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 33 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.3 mg/ml. lambdamax: 284 nm. SMILES: O=C(NC1=CC=CC(NC(NC(C2=CC(OC)=C(OC)C(OC)=C2)=O)=S)=C1)C3=CC=CC=C3. InChi Code: InChI=1S/C24H23N3O5S/c1-30-19-12-16(13-20(31-2)21(19)32-3)23(29)27-24(33)26-18-11-7-10-17(14-18)25-22(28)15-8-5-4-6-9-15/h4-14H,1-3H3,(H,25,28)(H2,26,27,29,33). InChi Key: KVQVEZQDNHMQJV-UHFFFAOYSA-N.