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SAG
SAG

Artikelnummer: Cay11914-1

Smoothened agonist (SAG) is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 µM). It directly binds to SMO and can block SMO inhibition by cyclopamine. Binding of SAG alters the conformation of SMO, leading to its...
Schlagworte: Smoothened Agonist,...
Anwendung: Smo Agonist
CAS 912545-86-9
MW: 490.1 D
ab 48,00 €
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-10 %
SAG . dihydrochloride (water soluble)
SAG . dihydrochloride (water soluble)

Artikelnummer: AG-CR1-3585-M005

Soluble in water or DMSO. Cell permeable Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Induces Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations....
Schlagworte: N-Methyl-N?-(3-pyridinylbenzyl)-N?-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane . 2HCl
Anwendung: SMO agonist
CAS 364590-63-6
MW: 581 D
55,00 € ab 49,50 €
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Vismodegib (GDC-0449), inhibitor
Vismodegib (GDC-0449), inhibitor

Artikelnummer: BPS-27010

.
Anwendung: Hedgehog signaling inhibitor
CAS 879085-55-9
MW: 421.3 D
191,00 €
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Cyclopamine, Free Base
Cyclopamine, Free Base

Artikelnummer: BPS-27013

Cyclopamine inhibits activation of the Hedgehog response pathway by binding to and inhibiting the proto-oncogene Smoothened (SMO). The effects of oncogenic mutations that either activate SMO or inactivate the tumor suppressor Patched (Ptch) can be reversed by cyclopamine treatment. Cyclopamine has also been shown to...
Anwendung: SMO inhibitor
MW: 411.6 D
276,00 €
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-10 %
SAG
SAG

Artikelnummer: AG-CR1-3506-M001

Cell permeable smoothened (Smo) agonist - Shown to induce Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo - Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations.
Schlagworte: N-Methyl-N'-(3-pyridinylbenzyl)-N'-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane
Anwendung: Smo Agonist
CAS 912545-86-9
MW: 490,1 D
55,00 € ab 49,50 €
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Nat-20(S)-yne
Nat-20(S)-yne

Artikelnummer: Cay9001369-1

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 µM), and this activation is selective for the...
Schlagworte: Click Tag(TM) Nat-20(S)-yne, 26,27-dinorcholest-5-en-24-yne-3beta,20-diol
Anwendung: Allosteric SMO activator
CAS 1397692-46-4
MW: 370.6 D
ab 82,00 €
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BMS 833923
BMS 833923

Artikelnummer: Cay16240-5

Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell...
Schlagworte: XL 139, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-benzamide
Anwendung: Smo inhibitor
CAS 1059734-66-5
MW: 473.6 D
ab 84,00 €
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-10 %
22-NHC . HCl
22-NHC . HCl

Artikelnummer: AG-CR1-3523-M001

Soluble in DMSO. Aza-steroid. Hedgehog signaling inhibitor. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo). For control compound see 22-NHC (inactive isomer) (Prod. No. AG-CR1-3524).
Schlagworte: 22-Azacholesterol, (3beta)-20S-[(3-Methylbutyl)amino]-pregn-5-en-3-ol
Anwendung: Hedgehog signaling inhibitor
CAS 360068-87-7
MW: 424,1 D
66,00 € ab 59,40 €
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LDE225 (phosphate)
LDE225 (phosphate)

Artikelnummer: Cay16263-1

LDE225 is a smoothened (Smo) antagonist (IC50s = 1.3 and 2.5 nM for mouse and human Smo, respectively). In vivo, LDE225 (20 mg/kg per day) inhibits Gli1 mRNA expression and prevents tumor growth in an orthotopic Ptch+/- p53-/- medulloblastoma mouse allograft model. Formulations containing LDE225 have been used in...
Schlagworte: Erismodegib, NVP-LDE225, Sonidegib,...
Anwendung: Smo antagonist
CAS 1218778-77-8
MW: 681.5 D
ab 43,00 €
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SANT 1
SANT 1

Artikelnummer: Cay14933-10

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. SANT 1 is a potent inhibitor of hedgehog signaling that acts by directly antagonizing SMO (IC50 = 20 nM). It counteracts SMO activation by the SMO agonist SAG...
Schlagworte: N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
Anwendung: SMO antagonist, Hedgehog signaling inhibitor
CAS 304909-07-7
MW: 373.5 D
ab 84,00 €
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GSA 10
GSA 10

Artikelnummer: Cay16164-10

Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of...
Schlagworte: 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-benzoic acid, propyl ester
Anwendung: SMO agonist
CAS 300833-95-8
MW: 450.5 D
ab 114,00 €
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LY2940680
LY2940680

Artikelnummer: Cay16264-1

LY2940680 is a smoothened (Smo) antagonist. It inhibits [35S]GTPgammaS binding in CHO cells expressing wild-type Smo (IC50 = 294 nM) and reduces production of GLI1 mRNA induced by sonic hedgehog (Shh) in Daoy cells (IC50 = 5.49 nM). Topical application of LY2940680 (2% w/v) decreases skin GLI1 and PTCH1 mRNA...
Schlagworte: Taladegib, 4-fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)-benzamide
Anwendung: Smo inhibitor
CAS 1258861-20-9
MW: 512.5 D
ab 82,00 €
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