MLE-4901

MLE-4901 is an antagonist of the neurokinin-3 (NK3) receptor. It inhibits human liver microsomal CYP3A4/5 with apparent IC50 values of 7.1 and 19.8 µM in midazolam 1'-hydroxylation and testosterone 6beta-hydroxylation assays, respectively.Formal Name: 3-[(methylsulfonyl)amino]-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide. CAS Number: 941690-55-7. Synonyms: AZD 2624, AZD 4901. Molecular Formula: C26H25N3O3S. Formula Weight: 459.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30mg/mL, DMF:PBS (pH 7.2) (1:3): 0.25mg/mL, DMSO: 20mg/mL. lambdamax: 236 nm. SMILES: CS(NC1=C(C(N[C@H](C2=CC=CC=C2)CC)=O)C3=CC=CC=C3N=C1C4=CC=CC=C4)(=O)=O. InChi Code: InChI=1S/C26H25N3O3S/c1-3-21(18-12-6-4-7-13-18)28-26(30)23-20-16-10-11-17-22(20)27-24(19-14-8-5-9-15-19)25(23)29-33(2,31)32/h4-17,21,29H,3H2,1-2H3,(H,28,30)/t21-/m0/s1. InChi Key: QYTBBBAHNIWFOD-NRFANRHFSA-N.