ML-324

ML-324 is a cell-permeable inhibitor of JMJD2E (KDM4DL, IC50 = 920 nM) that is inactive against lysine-specific demethylase, LSD1. It reduces the expression of immediate early genes of Herpes simplex virus (IC50 = ~10 µM) and human cytomegalovirus, blocks viral infection, and suppresses the level of viral reactivation in a ganglia explant model of latently infected mice. The effects of ML-324 are reversible, as viral replication resumes after drug withdrawal.Formal Name: N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)-benzamide. CAS Number: 1222800-79-4. Synonyms: CID-44143209. Molecular Formula: C21H23N3O2. Formula Weight: 349.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 204, 278 nm. SMILES: CN(C)CCCNC(C1=CC=C(C2=CC(C=CC=N3)=C3C(O)=C2)C=C1)=O. InChi Code: InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26). InChi Key: QDBVSOZTVKXUES-UHFFFAOYSA-N.