Zu "K06709" wurden 126 Artikel gefunden!
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Anti-KDM4A / JMJD2A / JHDM3A
Artikelnummer: NSJ-RQ7088
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Lysine-specific demethylase 4A is an enzyme that in humans is encoded by the KDM4A gene. This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two...
| Schlagworte: | Anti-KDM4A, Anti-JHDM3A, Anti-Lysine-specific demethylase 4A, Anti-Jumonji domain-containing protein 2A, Anti-[histone... |
| Anwendung: | WB, IHC (paraffin), FC, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
PFI-90
Artikelnummer: Cay40120-250
PFI-90 is an inhibitor of lysine demethylases (KDMs). It inhibits KDM3B, KDM4B, KDM5A, and KDM6B by 46.8 to 87.1% when used at a concentration of 10 µM. PFI-90 induces cell death in SJSA-1 osteosarcoma and TC-32 Ewing's sarcoma cancer cells (IC50s = 2 and 1 µM, respectively).Formal Name: 2-(2-pyridinyl)hydrazide,...
| Schlagworte: | 2-(2-pyridinyl)hydrazide, 2-pyridinecarboxylic acid |
| Anwendung: | KDM (lysine demethylase) inhibitor |
| CAS | 53995-62-3 |
| MW: | 214.2 D |
ab 64,00 €
Human KDM4A (Lysine Specific Demethylase 4A) ELISA Kit
Artikelnummer: ELK-ELK4412.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human KDM4A. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human KDM4A. Next,...
| Schlagworte: | KDM4A, JHDM3A, Lysine-specific demethylase 4A, Jumonji domain-containing protein 2A, [histone H3]-trimethyl-L-lysine(9)... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Anti-JMJD2A
Artikelnummer: A300-861A
Protein function: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no...
| Schlagworte: | Anti-KDM4A, Anti-JHDM3A, EC=1.14.11.-, Anti-Lysine-specific demethylase 4A, Anti-Jumonji domain-containing protein 2A,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 164,00 €
Anti-JMJD2B
Artikelnummer: A301-478A
Protein function: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and...
| Schlagworte: | Anti-KDM4B, Anti-JHDM3B, EC=1.14.11.-, Anti-Lysine-specific demethylase 4B, Anti-Jumonji domain-containing protein 2B,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 164,00 €
Anti-JMJD2C
Artikelnummer: A300-885A
Protein function: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no...
| Schlagworte: | Anti-GASC1, Anti-KDM4C, EC=1.14.11.-, Anti-GASC-1 protein, Anti-Lysine-specific demethylase 4C, Anti-Jumonji... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
N-Oxalylglycine
Artikelnummer: Cay13944-5
The jumonji domain-containing protein 2 (JMJD2) subfamily of histone demethylases have been shown to catalyze demethylation of the methylated forms of histone 3 lysine 9 (H3K9) and H3K36 in vitro and in cells. Because histone demethylases are implicated in certain diseases, including cancer, selective inhibitors are...
| Schlagworte: | NOG, N-(carboxycarbonyl)-glycine |
| Anwendung: | PHD1/PHD2 inhibitor |
| CAS | 5262-39-5 |
| MW: | 147.1 D |
ab 43,00 €
Anti-JMJD2B
Artikelnummer: A301-477A
Protein function: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and...
| Schlagworte: | Anti-KDM4B, Anti-JHDM3B, EC=1.14.11.-, Anti-Lysine-specific demethylase 4B, Anti-Jumonji domain-containing protein 2B,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
JMJD2C, active human recombinant protein
Artikelnummer: BPS-50105
Active human JMJD2C (GenBank Accession No. BC143571) (amino-acids 2-372) with N-terminal GST tag, MW=69 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | GASC1, KDM4C, GASC-1 protein, Lysine-specific demethylase 4C, Jumonji domain-containing protein 2C, [histone... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 69 kD |
686,00 €
JMJD2A(KDM4A) Active Human Recombinant Protein (1-350)
Artikelnummer: BPS-50123
Replaces JMJD2A, #BPS-50103, a.a. 1-480. Human JMJD2A, also known as JHDM3A and KDM4A (GenBank Accession No. NM_014663) (amino-acids 1-350) with N-terminal His-tag, MW=42 kDa, expressed in an E.coli expression system.
| Schlagworte: | KDM4A, JHDM3A, Lysine-specific demethylase 4A, Jumonji domain-containing protein 2A, [histone H3]-trimethyl-L-lysine(9)... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 42 kD |
686,00 €
JMJD2A (human, recombinant, His-tagged)
Artikelnummer: Cay10336-100
Jumonji Domain Containing 2A (JMJD2A) is a lysine-specific demethylase that catalyzes the demethylation of histone H3 at lysine residues 9 and 36 and histone H1.4 at lysine residue 26. It is composed of the JmjN N-terminal domain, JmjC catalytic domain, two plant homeodomains (PHDs), and two tudor domains that...
| Schlagworte: | KDM4A, JHDM3A, Lysine-specific demethylase 4A, Lysine-specific demethylase 4A, Jumonji domain-containing protein 2A,... |
| Anwendung: | Enzyme activity |
| MW: | 43 kD |
642,00 €
Methylstat (hydrate)
Artikelnummer: Cay11091-1
Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD3 with IC50 values of approximately 4.3, 3.4, 5.9, 10, and 43 µM, respectively, in an in vitro...
| Schlagworte: | 4-[hydroxy[4-[[[4-[[[(1-naphthalenylamino)carbonyl]oxy]methyl]phenyl]methyl]amino]butyl]amino]-4-oxo-2E-butenoic acid,... |
| Anwendung: | JMJD2A / JMJD2C / JMJD2E / PHF8 / JMJD3 inhibitor prodrug |
| MW: | 505.6 D |
ab 73,00 €