MIRA-1

MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 µM in vitro). Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner. At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone (Cay-11015), arrested tumor growth in a mouse xenograft model of multiple myeloma.Formal Name: 1-[(1-oxopropoxy)methyl]-1H-pyrrole-2,5-dione. CAS Number: 72835-26-8. Synonyms: NSC 19630. Molecular Formula: C8H9NO4. Formula Weight: 183.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 18.3 mg/ml, Ethanol: 18.3 mg/ml. lambdamax: 215 nm. SMILES: O=C1C=CC(N1COC(CC)=O)=O. InChi Code: InChI=1S/C8H9NO4/c1-2-8(12)13-5-9-6(10)3-4-7(9)11/h3-4H,2,5H2,1H3. InChi Key: YXEWPGYLMHXLPS-UHFFFAOYSA-N.