MA-0204

MA-0204 is an agonist of peroxisome proliferator-activated receptor delta (PPARdelta). It selectively induces reporter gene expression in CV-1 cells expressing human PPARdelta (EC50 = 0.4 nM) over CV-1 cells expressing human PPARalpha or PPARgamma (EC50s = 6,990 and >10,000 nM, respectively). MA-0204 increases the expression of mRNA encoding angiopoietin-related protein 4 (ANGPTL4), carnitine palmitoyltransferase 1 (CPT1), and pyruvate dehydrogenase kinase 4 (PDHK4) in primary myoblasts from a patient with Duchenne muscular dystrophy (DMD) in a concentration-dependent manner. In vivo, MA-0204 (30 or 100 mg/kg) increases the expression of mRNA encoding Pdhk4 in the skeletal muscle of mice.Formal Name: 3R-methyl-6-[2-[[5-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazol-1-yl]methyl]phenoxy]-hexanoic acid. CAS Number: 2095128-17-7. Molecular Formula: C25H27F3N2O4. Formula Weight: 476.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: C[C@@H](CC(O)=O)CCCOC1=CC=CC=C1CN2C(C3=CC=C(OC(F)(F)F)C=C3)=NC=C2C. InChi Code: InChI=1S/C25H27F3N2O4/c1-17(14-23(31)32)6-5-13-33-22-8-4-3-7-20(22)16-30-18(2)15-29-24(30)19-9-11-21(12-10-19)34-25(26,27)28/h3-4,7-12,15,17H,5-6,13-14,16H2,1-2H3,(H,31,32)/t17-/m1/s1. InChi Key: GYNMVDMBFKGCCR-QGZVFWFLSA-N.