Lofepramine

Lofepramine is a first generation tricyclic antidepressant that is extensively metabolized to desipramine. It potently inhibits serotonin and norepinephrine transporters (Kds = 70 and 5.4 nM, respectively) and less potently antagonizes serotonin, histamine, and muscarinic receptors.Formal Name: 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-ethanone. CAS Number: 23047-25-8. Synonyms: Lopramine. Molecular Formula: C26H27ClN2O. Formula Weight: 419.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 3 mg/ml. lambdamax: 251 nm. SMILES: CN(CC(C1=CC=C(Cl)C=C1)=O)CCCN2C3=C(C=CC=C3)CCC4=C2C=CC=C4. InChi Code: InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3. InChi Key: SAPNXPWPAUFAJU-UHFFFAOYSA-N.