Zu "K05035" wurden 114 Artikel gefunden!
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N-Desmethylcyclobenzaprine (hydrochloride)
Artikelnummer: Cay15906-1
An analytical reference standard categorized as an antidepressant, an active metabolite of amitriptyline and cyclobenzaprine, intended for research and forensic applications. Formulation: A solid. InChI: InChI=1S/C19H19N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19,/h2-5,7-13,20H,6,14H2,1H3,1H....
| Schlagworte: | 10,11-Dehydronortriptyline, N 7068, Ro 4-6011, 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine,... |
| Anwendung: | Analytical reference standard, antidepressant, active amitriptyline/cyclobenzaprine metabolite |
| CAS | 438-59-5 |
| MW: | 297.8 D |
ab 208,00 €
Liafensine
Artikelnummer: TGM-T32737-5mg
Description: Liafensine(BMS-820836) is a novel and selective triple monoamine reuptake inhibitor with inhibitory effects on the reuptake of serotonin, norepinephrine, and dopamine for the study of major depressive disorder and central nervous system disorders. Target: Norepinephrine, 5-HT Receptor, Dopamine...
| Schlagworte: | BMS-820836, DB104, BMS820836, BMS 820836 |
| Anwendung: | Targets solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 (SLC6A4, SERT) |
| CAS | 1198790-53-2 |
| MW: | 366.46 D |
ab 365,00 €
Trimipramine (maleate)
Artikelnummer: Cay15921-1
Trimipramine is a tricyclic antidepressant. It selectively binds the serotonin (5-HT) transporter (SERT) over the norepinephrine transporter (NET) and dopamine transporter (DAT, Kds = 149, 2,450, and 3,780 nM, respectively) and acts as a histamine H1 receptor antagonist (Ki = 0.02 µM) that is selective for histamine...
| Schlagworte: | 10,11-dihydro-N,N,beta-trimethyl-5H-dibenz[b,f]azepine-5-propanamine, (2Z)-2-butenedioate |
| Anwendung: | Noradrenalin transporter inhibitor, serotonin transporter inhibitor |
| CAS | 521-78-8 |
| MW: | 410.5 D |
ab 52,00 €
Guanethidine (sulfate)
Artikelnummer: Cay16217-100
Guanethidine is an antihypertensive compound that competes with norepinephrine for transport into presynaptic terminals of adrenergic neurons by the norepinephrine transporter. Once guanethidine has entered the nerve, it becomes concentrated in synaptic vesicles, depleting endogenous norepinephrine, and thus,...
| Schlagworte: | N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-guanidine, monosulfate |
| Anwendung: | Antihypertensive compound |
| CAS | 645-43-2 |
| MW: | 296.4 D |
ab 85,00 €
Nomifensine
Artikelnummer: Cay29330-25
Nomifensine is an inhibitor of norepinephrine (NE) and dopamine (DA) reuptake. It inhibits uptake of NE, DA, and serotonin (5-HT) in rat brain synaptosomes with IC50 values of 6.6, 48, and 830 nM, respectively. It is selective for DA, NE, and 5-HT uptake inhibition over binding to dopamine D2, alpha1- adrenergic-,...
| Schlagworte: | (±)-Nomifensine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine |
| Anwendung: | Noradrenaline reuptake inhibitor (NRI) |
| CAS | 24526-64-5 |
| MW: | 238.3 D |
ab 67,00 €
Lofepramine
Artikelnummer: Cay20813-1
Lofepramine is a first generation tricyclic antidepressant that is extensively metabolized to desipramine. It potently inhibits serotonin and norepinephrine transporters (Kds = 70 and 5.4 nM, respectively) and less potently antagonizes serotonin, histamine, and muscarinic receptors.Formal Name:...
| Schlagworte: | Lopramine, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-ethanone |
| Anwendung: | Antidepressant, serotonin-noradrenaline reuptake inhibitor (SNRI) |
| CAS | 23047-25-8 |
| MW: | 419 D |
ab 49,00 €
Duloxetine Hydrochloride
Artikelnummer: LKT-D8145.100
Duloxetine is a serotonin/norepinephrine reuptake inhibitor (SNRI). It is used as an antidepressant and anxiolytic.
| Schlagworte: | LY-248686 hydrochloride, Cymbalta, Ariclaim, (+)-(S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine... |
| CAS | 136434-34-9 |
| MW: | 333.88 D |
ab 128,00 €
Anti-Norepinephrine Transporter, clone NET-05
Artikelnummer: ARG11072.100
Protein function: Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. [The UniProt Consortium]
| Schlagworte: | Anti-NET, Anti-Slc6a2, Anti-Norepinephrine transporter, Anti-Solute carrier family 6 member 2, Anti-Sodium-dependent... |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | mouse, rat |
1.184,00 €
Reboxetine (mesylate)
Artikelnummer: Cay15038-10
Reboxetine is an antidepressant compound that selectively inhibits norepinephrine uptake (IC50s = 8.2 and 1,070 nM for norepinephrine and serotonin transporters, respectively). It displays greater than 1,000-fold affinity for binding rat norepinephrine receptors compared to serotonin, histamine, acetylcholine, or...
| Schlagworte: | Davedax, Edronax, FCE 20124, PNU 155950E, (2R)-rel-2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-morpholine, methanesulfonate |
| Anwendung: | Norepinephrine uptake inhibitor, noradrenalin transporter inhibitor |
| CAS | 98769-84-7 |
| MW: | 409.5 D |
ab 93,00 €
(S)-Duloxetine (hydrochloride)
Artikelnummer: Cay14317-25
(S)-Duloxetine is a potent inhibitor of serotonin and norepinephrine reuptake (Kis = 4.6 and 15.6 nM, respectively, for rat synaptosomes). It also inhibits dopamine reuptake (Ki = 369 nM). (S)-Duloxetine suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 µg/kg,...
| Schlagworte: | LY248686, N-methyl-gammaS-(1-naphthalenyloxy)-2-thiophenepropanamine, monohydrochloride |
| Anwendung: | Serotonin and norepinephrine reuptake inhibitor |
| CAS | 136434-34-9 |
| MW: | 333.9 D |
ab 49,00 €
Nortriptyline (hydrochloride)
Artikelnummer: Cay15904-100
Nortriptyline is a tricyclic antidepressant that blocks norepinephrine and serotonin (Cay-14332) transporters (KDs = 4.4 and 18 nM, respectively) more potently than the dopamine transporter (KD = 1.1 µM). It also antagonizes serotonin, histamine, muscarinic, and alpha-adrenergic receptors (Kis = 5.0, 8.5, 10, 40,...
| Schlagworte: | Acetexa, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, monohydrochloride |
| Anwendung: | Serotonin norepinephrine reuptake inhibitor |
| CAS | 894-71-3 |
| MW: | 299.8 D |
ab 49,00 €
Atomoxetine (hydrochloride)
Artikelnummer: Cay22248-10
Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki values of 5, 77, and 1,451 nM for norepinephrine, serotonin, and dopamine transporters, respectively. It is selective over the choline, GABA, and adenosine transporters, and a number of neurotransmitter receptors, ion channels, second messengers,...
| Schlagworte: | LY139603, N-methyl-gammaR-(2-methylphenoxy)-benzenepropanamine, monohydrochloride |
| Anwendung: | Selective noradrenaline reuptake inhibitor (NRI) |
| CAS | 82248-59-7 |
| MW: | 291.8 D |
ab 110,00 €