Levobetaxolol (hydrochloride)

Levobetaxolol is an isomer of betaxolol (Cay-18625) and antagonist of the beta1-adrenergic receptor (beta1-AR, Ki = 0.76 nM for the human receptor). It is selective for beta1-ARs over beta2-ARs (Ki = 32.6 nM), as well as a panel of 89 additional receptors (IC50s = >1 µM). Levobetaxolol inhibits cAMP production induced by isoproterenol (Cay-15592) in human non-pigmented ciliary epithelial cells (Ki = 16.4 nM). Topical application of levobetaxolol (150 µg/eye) reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension. Formulations containing levobetaxolol have been used in the treatment of glaucoma.Formal Name: (2S)-1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol, monohydrochloride. CAS Number: 116209-55-3. Synonyms: (S)-Betaxolol. Molecular Formula: C18H29NO3 . HCl. Formula Weight: 343.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: CC(C)NC[C@H](O)COC1=CC=C(C=C1)CCOCC2CC2.Cl. InChi Code: InChI=1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16,/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3,1H/t17-,/m0./s1. InChi Key: CHDPSNLJFOQTRK-LMOVPXPDSA-N.