L82-G17

L82-G17 is an uncompetitive inhibitor of DNA ligase I. It increases the retention of DNA ligase I, but not DNA ligase III, on nicked DNA-coated beads in a cell-free assay, as well as decreases the proliferation of HeLa cells when used at a concentration of 20 µM.Formal Name: 4-chloro-5-(2-(3-hydroxybenzylidene)hydrazineyl)pyridazin-3(2H)-one. CAS Number: 92285-87-5. Molecular Formula: C11H9ClN4O2. Formula Weight: 264.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/mL. SMILES: O=C1NN=CC(NN=CC2=CC(O)=CC=C2)=C1Cl. InChi Code: InChI=1S/C11H9ClN4O2/c12-10-9(6-14-16-11(10)18)15-13-5-7-2-1-3-8(17)4-7/h1-6,17H,(H2,15,16,18). InChi Key: PYYWVUBALUMAIY-UHFFFAOYSA-N.