L-742,001 (hydrochloride)

L-742,001 is an inhibitor of influenza virus PA endonuclease (IC50 = 0.5 µM), an essential subdomain of the viral RNA polymerase. It reduces viral titers in PR8 influenza-infected MDCK cells when used at a concentration of 10 µM.Formal Name: 4-[4-[(4-chlorophenyl)methyl]-1-(phenylmethyl)-4-piperidinyl]-2-hydroxy-4-oxo-2-butenoic acid, monohydrochloride. CAS Number: 174605-64-2. Molecular Formula: C23H24ClNO4 . HCl. Formula Weight: 450.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: O=C(C(O)=CC(C1(CCN(CC1)CC2=CC=CC=C2)CC3=CC=C(C=C3)Cl)=O)O.Cl. InChi Code: InChI=1S/C23H24ClNO4.ClH/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18./h1-9,14,26H,10-13,15-16H2,(H,28,29).1H. InChi Key: LMLNSXCRZNNZBT-UHFFFAOYSA-N.