L-701,324

L-701,324 is an NMDA receptor antagonist. It inhibits NMDA-induced currents in rat cortical neurons (Ki = 5.4 nM). L-701,324 inhibits seizures induced by N-methyl-DL-aspartate, pentylenetetrazole (PTZ, Cay-18682), or electroshock, as well as audiogenic seizures in mice (ED50s = 3.5, 2.8, 1.4, and 0.96 mg/kg, respectively). It reduces the number of audiogenic seizures in a rat model of ethanol-induced withdrawal seizures when administered at a dose of 5 mg/kg. L-701,324 (2.5 and 5 mg/kg) reduces amphetamine-induced hyperactivity in rats.Formal Name: 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-2(1H)-quinolinone. CAS Number: 142326-59-8. Molecular Formula: C21H14ClNO3. Formula Weight: 363.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml, DMSO: 15 mg/ml. lambdamax: 226 nm. SMILES: ClC1=CC=C2C(NC(C(C3=CC(OC4=CC=CC=C4)=CC=C3)=C2O)=O)=C1. InChi Code: InChI=1S/C21H14ClNO3/c22-14-9-10-17-18(12-14)23-21(25)19(20(17)24)13-5-4-8-16(11-13)26-15-6-2-1-3-7-15/h1-12H,(H2,23,24,25). InChi Key: FLVRDMUHUXVRET-UHFFFAOYSA-N.