L-165,041

L-165,041 is a potent and selective agonist of the nuclear receptor PPARbeta/delta (Ki = 9 nM, EC50 = ~500 nM for hPPARbeta/delta). It is less effective against PPARalpha and PPARgamma, with activity at those receptors depending on cell type and system of study. L-165,041 is used to evaluate the diverse roles of PPARbeta/delta, including those related to cholesterol metabolism, inflammation, and neuroprotection.Formal Name: 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-acetic acid. CAS Number: 79558-09-1. Molecular Formula: C22H26O7. Formula Weight: 402.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 30 mg/ml. lambdamax: 222, 284 nm. SMILES: CC(C1=CC=C(OCCCOC2=CC=C(OCC(O)=O)C=C2)C(CCC)=C1O)=O. InChi Code: InChI=1S/C22H26O7/c1-3-5-19-20(11-10-18(15(2)23)22(19)26)28-13-4-12-27-16-6-8-17(9-7-16)29-14-21(24)25/h6-11,26H,3-5,12-14H2,1-2H3,(H,24,25). InChi Key: HBBVCKCCQCQCTJ-UHFFFAOYSA-N.