Ku-55933

Ku-55933 is a potent ATP-competitive inhibitor of the ataxia-telangiectasia mutated (ATM) kinase (IC50 = 13 nM, Ki = 2.2 nM). Inhibition of ATM by Ku-55933 blocks radiation-induced phosphorylation of downstream cellular targets and sensitizes cells to the cytotoxic effects of both ionizing radiation and chemotherapeutic agents. Ku-55933 induces senescent breast, lung, and colon carcinoma cells to undergo cell death. It also inhibits HIV-1 replication in C8166 human T-lymophocyte cells with an IC50 value of 2.4 µM.Formal Name: 2-(4-morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one. CAS Number: 587871-26-9. Synonyms: ATM Kinase Inhibitor. Molecular Formula: C21H17NO3S2. Formula Weight: 395.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. lambdamax: 246 nm. SMILES: O=C1C=C(C2=C(SC(C=CC=C3)=C3S4)C4=CC=C2)OC(N5CCOCC5)=C1. InChi Code: InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2. InChi Key: XRKYMMUGXMWDAO-UHFFFAOYSA-N.