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Zu "K04728" wurden 93 Artikel gefunden!
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Artikelnummer: 200-301-400
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of...
Schlagworte: | Anti-phospho-ATM, Anti-phospho-A-T mutated, EC=2.7.11.1, Anti-phospho-Serine-protein kinase ATM, Anti-phospho-Ataxia... |
Anwendung: | ELISA, FC, IHC, IFM, WB |
Wirt: | Mouse |
Spezies-Reaktivität: | human, mouse, rat |
ab 180,00 €
Artikelnummer: A300-299A-T
Ataxia telangiectasia, mutated (ATM) is the gene responsible for the neurodegenerative disease ataxia telangiectasia (AT). AT is characterized by neurodegeneration, immune dysfunction, sensitivity to DNA damage, and cancer predisposition. ATM is a protein kinase central to the DNA damage response. In response to DNA...
Schlagworte: | Anti-ATM, Anti-A-T mutated, Anti-Serine-protein kinase ATM, Anti-Ataxia telangiectasia mutated |
Anwendung: | WB, IP, IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
164,00 €
-10 %
Rabattaktion
Artikelnummer: ELK-ELK1896.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ATM. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ATM. Next,...
Schlagworte: | ATM, A-T mutated, Serine-protein kinase ATM, Ataxia telangiectasia mutated |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
365,00 €
ab 328,50 €
-10 %
Rabattaktion
Artikelnummer: ELK-ELK4506.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse ATM. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse ATM. Next,...
Schlagworte: | Atm, A-T mutated homolog, Serine-protein kinase ATM, Ataxia telangiectasia mutated homolog |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
365,00 €
ab 328,50 €
-10 %
Rabattaktion
Artikelnummer: ELK-EA323.100
Ataxia telangiectasia mutated kinase (ATM) is a serine/threonine kinase that regulates cell cycle checkpoints and DNA repair. ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis, and DNA repair. Protein function: Serine/threonine protein kinase which activates checkpoint...
Schlagworte: | Anti-ATM, Anti-A-T mutated, Anti-Serine-protein kinase ATM, Anti-Ataxia telangiectasia mutated, ATM Rabbit pAb |
Anwendung: | IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
283,00 €
254,70 €
Artikelnummer: Cay39183-1
A011 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase (IC50 = 1 nM). It is selective for ATM over a panel of 408 additional kinases at 10 µM. A011 inhibits the growth of SW620 and HCT116 colorectal cancer cells (IC50s = 0.14 and 0.91 µM, respectively) and enhances cell death induced by DNA topoisomerase...
Schlagworte: | (R)-N,N-dimethyl-3-((5-(1-(1-phenylethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-8-yl)pyridin-2-yl)oxy)propan-1-amine |
Anwendung: | ATM kinase inhibitor |
MW: | 452.6 D |
ab 77,00 €
Artikelnummer: 200-301-500
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of...
Schlagworte: | Anti-phospho-ATM, Anti-phospho-A-T mutated, EC=2.7.11.1, Anti-phospho-Serine-protein kinase ATM, Anti-phospho-Ataxia... |
Anwendung: | ELISA, FC, IHC, WB |
Wirt: | Mouse |
Spezies-Reaktivität: | human, mouse |
756,00 €
Artikelnummer: 600-401-398
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of...
Schlagworte: | Anti-ATM, Anti-A-T mutated, EC=2.7.11.1, Anti-Serine-protein kinase ATM, Anti-Ataxia telangiectasia mutated |
Anwendung: | ELISA, IHC, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
684,00 €
Artikelnummer: A300-136A
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of...
Schlagworte: | Anti-ATM, EC=2.7.11.1, Anti-A-T mutated, Anti-Serine-protein kinase ATM, Anti-Ataxia telangiectasia mutated |
Anwendung: | WB, IP |
Wirt: | Goat |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: Cay16336-1
Ku-55933 is a potent ATP-competitive inhibitor of the ataxia-telangiectasia mutated (ATM) kinase (IC50 = 13 nM, Ki = 2.2 nM). Inhibition of ATM by Ku-55933 blocks radiation-induced phosphorylation of downstream cellular targets and sensitizes cells to the cytotoxic effects of both ionizing radiation and...
Schlagworte: | ATM Kinase Inhibitor, 2-(4-morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one |
Anwendung: | Potent ATP-competitive ATM kinase inhibitor |
CAS | 587871-26-9 |
MW: | 395.5 D |
ab 38,00 €
Artikelnummer: Cay36498-1
AZD 1390 is an inhibitor of Ataxia-telangiectasia mutated (ATM) kinase (IC50 = 0.78 nM). It is selective for ATM over Ataxia-telangiectasia and Rad3-related protein/kinase (ATR), PI3K, mammalian target of rapamycin (mTOR), and DNA protein kinase (DNA-PK, IC50s = >30, >12, >16, and >29.9 µM, respectively). AZD 1390...
Schlagworte: | 7-fluoro-1,3-dihydro-3-methyl-1-(1-methylethyl)-8-[6-[3-(1-piperidinyl)propoxy]-3-pyridinyl]-2H-imidazo[4,5-c]quinolin-2-one |
Anwendung: | ATM kinase inhibitor |
CAS | 2089288-03-7 |
MW: | 477.6 D |
ab 68,00 €
Artikelnummer: A300-299A
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of...
Schlagworte: | Anti-ATM, EC=2.7.11.1, Anti-A-T mutated, Anti-Serine-protein kinase ATM, Anti-Ataxia telangiectasia mutated |
Anwendung: | WB, IP, IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
588,00 €