JZP 430

JZP 430 is an inhibitor of alpha/beta-hydrolase domain-containing protein 6 (ABHD6, IC50 = 0.044 for the human enzyme). It is selective for ABHD6 over fatty acid amid hydrolase (FAAH) and monoacylglycerol lipase (MAGL) when used at a concentration of 2.5 µM, ABHD12 at 1 µM, as well as lysosomal acid lipase (LAL) and cannabinoid 1 (CB1) and CB2 receptors at 10 µM.Formal Name: N-cyclooctyl-N-methyl-carbamic acid, 4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl ester. CAS Number: 1672691-74-5. Molecular Formula: C16H26N4O3S. Formula Weight: 354.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): insol. lambdamax: 206, 210, 302 nm. SMILES: O=C(OC1=NSN=C1N2CCOCC2)N(C)C3CCCCCCC3. InChi Code: InChI=1S/C16H26N4O3S/c1-19(13-7-5-3-2-4-6-8-13)16(21)23-15-14(17-24-18-15)20-9-11-22-12-10-20/h13H,2-12H2,1H3. InChi Key: WKSHMJCYWFOADB-UHFFFAOYSA-N.