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Zu "K13700" wurden 17 Artikel gefunden!
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Artikelnummer: Cay10011213-10
WWL70 is an inhibitor of alpha/beta-hydrolase domain-containing protein 6 (ABHD6, IC50 = 70 nM). It increases the expression of the adipose browning-related gene Ucp1 in differentiated 3T3-L1 mouse adipocytes and increases the oxygen consumption rate (OCR), an effect that can be blocked by the PPARalpha antagonist...
Schlagworte: | N-methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-carbamic acid, 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester |
Anwendung: | ABHD6 inhibitor |
CAS | 947669-91-2 |
MW: | 437.5 D |
ab 61,00 €
Artikelnummer: Cay14818-1
The serine hydrolase known as alpha/beta-hydrolase domain-containing protein 6 (ABHD6) hydrolyzes 2-arachidonoyl glycerol (2-AG, Cay-62160) to regulate its availability at cannabinoid receptors. KT195 is a selective inhibitor of ABHD6 (IC50 = 10 nM) with negligible activity against other serine hydrolases such as...
Schlagworte: | ML-295, [4-(4'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone |
Anwendung: | ABHD6 inhibitor |
CAS | 1402612-58-1 |
MW: | 438.5 D |
ab 43,00 €
Artikelnummer: Cay35383-5
JZP 430 is an inhibitor of alpha/beta-hydrolase domain-containing protein 6 (ABHD6, IC50 = 0.044 for the human enzyme). It is selective for ABHD6 over fatty acid amid hydrolase (FAAH) and monoacylglycerol lipase (MAGL) when used at a concentration of 2.5 µM, ABHD12 at 1 µM, as well as lysosomal acid lipase (LAL) and...
Schlagworte: | N-cyclooctyl-N-methyl-carbamic acid, 4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl ester |
Anwendung: | ABHD6 inhibitor |
CAS | 1672691-74-5 |
MW: | 354.5 D |
ab 163,00 €
Artikelnummer: Cay14819-5
KT203 is a potent inhibitor of alpha/beta-hydrolase domain-containing protein 6 (ABHD6) with IC50 values of 0.82, 3.9, and 0.31 nM using Neuro2A membrane proteomes, recombinant ABHD6 in HEK293T cells, and Neuro2A cells in situ, respectively. Following administration of KT203 (1 mg/kg, i.p.) in mice, ABHD6 is...
Schlagworte: | ML-296, 4'-[1-[[2-(phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1'-biphenyl]-3-carboxylic acid |
Anwendung: | ABHD6 inhibitor |
CAS | 1402612-64-9 |
MW: | 466.5 D |
ab 50,00 €
Artikelnummer: Cay15404-5
KT182 is a potent inhibitor of alpha/beta-hydrolase domain-containing protein 6 (ABHD6) with IC50 values of 1.7, 15.1, and 0.24 nM using Neuro2a membrane proteomes, recombinant ABHD6 in HEK293T cells, and Neuro2a cells in situ, respectively. Following administration of KT182 (1 mg/kg, i.p.) in mice, ABHD6 is...
Schlagworte: | [4-[3'-(hydroxymethyl)[1,1'-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone |
Anwendung: | ABHD6 inhibitor |
CAS | 1402612-62-7 |
MW: | 438.5 D |
ab 50,00 €
Artikelnummer: Cay16849-1
The serine hydrolase known as alpha/beta-hydrolase domain-containing protein 6 (ABHD6) hydrolyzes 2-arachidonoyl glycerol (Cay-62160) to regulate its availability at cannabinoid receptors. WWL123 is a brain-penetrant inhibitor of ABHD6 (IC50 = 0.43 µM) that demonstrates >10-fold selectivity for ABHD6 compared to a...
Schlagworte: | N-([1,1'-biphenyl]-3-ylmethyl)-N-methyl-carbamic acid, 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester |
Anwendung: | ABHD6 inhibitor |
CAS | 1338574-83-6 |
MW: | 436.5 D |
ab 61,00 €
Artikelnummer: Cay19113-10
KT185 is an orally bioavailable inhibitor of alpha/beta-hydrolase domain-containing protein 6 (ABHD6) with an IC50 value of 0.21 nM in a competitive activity-based protein profiling assay using Neuro2A membranes. It inhibits ABHD6 in a 2-arachidonoyl glycerol (2-AG, Cay-62160) hydrolysis assay (IC50 = 13.6 nM for...
Schlagworte: | [4'-[1-[(2-phenyl-1-piperidinyl)carbonyl]-1H-1,2,3-triazol-4-yl][1,1'-biphenyl]-3-yl]-1-piperidinyl-methanone |
Anwendung: | ABHD6 inhibitor |
CAS | 1472640-86-0 |
MW: | 519.6 D |
ab 125,00 €
Artikelnummer: ATA-HPA073225.100
Protein function: Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for...
Schlagworte: | Anti-Monoacylglycerol lipase ABHD6, Anti-2-arachidonoylglycerol hydrolase, Anti-Abhydrolase domain-containing protein 6 |
Anwendung: | ICC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 335,00 €
Artikelnummer: ELK-ES1573.100
catalytic activity:Hydrolyzes glycerol monoesters of long-chain fatty acids.,function:Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways.,similarity:Belongs to the AB hydrolase superfamily., Protein function: Lipase that preferentially hydrolysis...
Schlagworte: | Anti-Monoacylglycerol lipase ABHD6, Anti-2-arachidonoylglycerol hydrolase, Anti-Abhydrolase domain-containing protein 6,... |
Anwendung: | WB, IF, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 169,00 €
Artikelnummer: VHPS-59
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
Schlagworte: | ABHD6, EC=3.1.1.23, Monoacylglycerol lipase ABHD6, 2-arachidonoylglycerol hydrolase, Abhydrolase domain-containing protein 6 |
Anwendung: | RNA quantification |
43,00 €
Artikelnummer: VMPS-52
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
Schlagworte: | Abhd6, EC=3.1.1.23, Monoacylglycerol lipase ABHD6, 2-arachidonoylglycerol hydrolase, Abhydrolase domain-containing protein 6 |
Anwendung: | RNA quantification |
43,00 €
Artikelnummer: VRPS-54
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
Schlagworte: | Abhd6, EC=3.1.1.23, Monoacylglycerol lipase ABHD6, 2-arachidonoylglycerol hydrolase, Abhydrolase domain-containing protein 6 |
Anwendung: | RNA quantification |
52,00 €