JNK Inhibitor VIII

JNK inhibitor VIII is an inhibitor of JNK1, JNK2, and JNK3 (Kis= 2, 4, and 52 nM, respectively). It is selective for JNK1, JNK2, and JNK3 over a panel of 74 kinases (Kis = >720 nM for all). It inhibits the phosphorylation of c-Jun in HepG2 cells (EC50 = 920 nM). JNK inhibitor VIII (10 µM) inhibits NGF-induced neuronal growth and proNGF-induced neurotoxicity of primary mouse superior cervical ganglion neurons. It reduces apoptosis induced by glutathione peroxidase 1 (GPX1) siRNA knockdown in HeLa cells when used at a concentration of 10 µM.Formal Name: N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-benzeneacetamide. CAS Number: 894804-07-0. Synonyms: c-Jun N-terminal Kinase Inhibitor VIII, TCS JNK 6o. Molecular Formula: C18H20N4O4. Formula Weight: 356.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 230, 274 nm. SMILES: COC1=CC(CC(NC2=CC(N)=C(C#N)C(OCC)=N2)=O)=C(OC)C=C1. InChi Code: InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23). InChi Key: KQMPRSZTUSSXND-UHFFFAOYSA-N.