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JNK Inhibitor VIII
Artikelnummer: Cay15946-5
JNK inhibitor VIII is an inhibitor of JNK1, JNK2, and JNK3 (Kis= 2, 4, and 52 nM, respectively). It is selective for JNK1, JNK2, and JNK3 over a panel of 74 kinases (Kis = >720 nM for all). It inhibits the phosphorylation of c-Jun in HepG2 cells (EC50 = 920 nM). JNK inhibitor VIII (10 µM) inhibits NGF-induced...
| Schlagworte: | c-Jun N-terminal Kinase Inhibitor VIII, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-benzeneacetamide |
| Anwendung: | JNK1 / JNK2 / JNK3 inhibitor |
| CAS | 894804-07-0 |
| MW: | 356.4 D |
ab 151,00 €
JNK Inhibitor VIII
Artikelnummer: TGM-T7677-5mg
Description: JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive, selective inhibitor of c-Jun N-terminal kinase (JNK) with IC50 values of 45 nM for JNK-1 and 160 nM for JNK-2. Target: JNK. Smiles: CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N. References: Szczepankiewicz BG, et al. Aminopyridine-based c-Jun N-terminal...
| Schlagworte: | TCS JNK 6o |
| Anwendung: | JNK inhibitor |
| CAS | 894804-07-0 |
| MW: | 356.38 D |
ab 52,00 €
