Zu "K04440" wurden 249 Artikel gefunden!
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SR 3306
Artikelnummer: Cay45342-1
SR 3306 is a pan-JNK inhibitor (IC50s = 67, 283, and 159 nM for JNK1, JNK2, and JNK3, respectively). It is selective for JNK1-3 over p38 MAPK (IC50 = >20 µM). SR 3306 (300-1,000 nM) reduces cell death induced by N-methyl-4-phenylpyridinium (MPP+) in primary rat mesencephalic dopaminergic neurons. It reduces MPTP- or...
| Schlagworte: | N-[4-[3-(6-methyl-3-pyridinyl)-1H-1,2,4-triazol-1-yl]phenyl]-4-[3-(4-morpholinyl)phenyl]-2-pyrimidinamine |
| Anwendung: | Pan-JNK inhibitor |
| CAS | 1128096-91-2 |
| MW: | 490.57 D |
ab 55,00 €
JNK1 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-04019-100ug
Description: JNK1 Protein, Human, Recombinant (His) is expressed in Baculovirus Insect Cells with N-6xHis. The accession number is P45983.
| Schlagworte: | Mitogen-activated protein kinase 8 , Stress-activated protein kinase JNK1 , MAPK 8 , SAPK1C , MAP kinase 8 , SAPK1 ,... |
| MW: | 49.4 kD |
ab 125,00 €
IQ-3
Artikelnummer: Cay44645-10
IQ-3 is a JNK inhibitor. It is selective for JNKs over a panel of 131 kinases at 10 µM. IQ-3 binds to JNKs (Kd = 0. 0. and 0. µM for JNK1-3), as well as casein kinase 1delta (CK1delta), PI3Kgamma, and MAPK-interacting serine/threonine kinase 2 (MKNK2. Kds = 0. 0. and 1. µM, respectively). It also inhibits...
| Schlagworte: | O-(2-furanylcarbonyl)oxime 11H-indeno[1,2-b]quinoxalin-11-one |
| Anwendung: | JNK inhibitor |
| CAS | 312538-03-7 |
| MW: | 341.33 D |
ab 104,00 €
Anti-Recombinant Phospho-JNK1, 2, 3 (Thr183, Thr183,...
Artikelnummer: E-AN301149L.100
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by...
| Schlagworte: | Anti-MAPK8, Anti-JNK-46, Anti-c-Jun N-terminal kinase 1, Anti-Mitogen-activated protein kinase 8, Anti-Stress-activated... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-Recombinant JNK2, clone 3P10
Artikelnummer: E-AN300611L.100
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific...
| Schlagworte: | Anti-MAPK9, Anti-JNK-55, Anti-c-Jun N-terminal kinase 2, Anti-Mitogen-activated protein kinase 9, Anti-Stress-activated... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-JNK1, clone 29M34
Artikelnummer: NSJ-RQ8844
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA.
| Schlagworte: | Anti-MAPK8, Anti-JNK-46, Anti-c-Jun N-terminal kinase 1, Anti-Mitogen-activated protein kinase 8, Anti-Stress-activated... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
SP600125
Artikelnummer: Cay10010466-10
SP6000125 is a pan-inhibitor of JNK (IC50s = 0.04, 0.04, and 0.09 µM for JNK1, -2, and -3, respectively). It is greater than 300-fold selective for these enzymes over a panel of 17 additional kinases at 10 µM. SP6000125 reduces LPS-induced production of IL-1beta, IL-8, and TNF-alpha in isolated human peripheral...
| Schlagworte: | 1PMV, NSC 75890, Pyrazolanthrone, anthra[1,9-cd]pyrazol-6(2H)-one |
| Anwendung: | JNK inhibitor |
| CAS | 129-56-6 |
| MW: | 220.2 D |
ab 70,00 €
JNK Inhibitor VIII
Artikelnummer: Cay15946-5
JNK inhibitor VIII is an inhibitor of JNK1, JNK2, and JNK3 (Kis= 2, 4, and 52 nM, respectively). It is selective for JNK1, JNK2, and JNK3 over a panel of 74 kinases (Kis = >720 nM for all). It inhibits the phosphorylation of c-Jun in HepG2 cells (EC50 = 920 nM). JNK inhibitor VIII (10 µM) inhibits NGF-induced...
| Schlagworte: | c-Jun N-terminal Kinase Inhibitor VIII, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-benzeneacetamide |
| Anwendung: | JNK1 / JNK2 / JNK3 inhibitor |
| CAS | 894804-07-0 |
| MW: | 356.4 D |
ab 157,00 €
CC-930
Artikelnummer: Cay22466-1
CC-930 is an orally bioavailable and potent inhibitor of JNKs (IC50s = 61, 7, and 6 nM for JNK1, JNK2, and JNK3, respectively). It is selective for MAP kinases over a panel of 240 kinases, showing greater than 50% inhibition at only one non-MAP kinase target, EGFR (IC50 = 380 nM). Within the MAPK family, it is...
| Schlagworte: | Tanzisertib, trans-4-[[9-[(3S)-tetrahydro-3-furanyl]-8-[(2,4,6-trifluorophenyl)amino]-9H-purin-2-yl]amino]-cyclohexanol |
| Anwendung: | JNK inhibitor |
| CAS | 899805-25-5 |
| MW: | 448.4 D |
ab 57,00 €
JNK1 alpha2 Isoform (human, recombinant)
Artikelnummer: Cay43698-50
Protein function: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress- activated protein kinase/c-Jun N-terminal...
| Schlagworte: | JNK1, MAPK8, SAPK1c, MAPK 8, JNK-46, MAP kinase 8, c-Jun N-terminal kinase 1, Stress-activated protein kinase 1c,... |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
304,00 €
JNK2 alpha2 Isoform (human, recombinant)
Artikelnummer: Cay43699-50
Protein function: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress- activated protein kinase/c-Jun N-terminal...
| Schlagworte: | JNK2, MAPK9, SAPK1a, MAPK 9, JNK-55, MAP kinase 9, c-Jun N-terminal kinase 2, Mitogen-activated protein kinase 9,... |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
ab 380,00 €
CC-401
Artikelnummer: Cay18867-1
c-Jun N-terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens. CC-401 is a potent inhibitor of all three JNK isoforms (Ki values range from 25 to 50 nM). It has at least...
| Schlagworte: | 3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole |
| Anwendung: | JNK inhibitor |
| CAS | 395104-30-0 |
| MW: | 388.5 D |
ab 164,00 €