JNJ-26483327

Artikelnummer	Größe	Manual	Lieferzeit	Preis
Cay44468-1	1 mg	-	6 - 10 Werktage*	209,00 €
Cay44468-5	5 mg	-	6 - 10 Werktage*	992,00 €
Cay44468-10	10 mg	-	6 - 10 Werktage*	1.671,00 €

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JNJ-26483327 is an inhibitor of Met. It also inhibits EGFR, HER2, and HER4 (IC50s = 9.6, 18, and... mehr

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Produktinformationen "JNJ-26483327"

JNJ-26483327 is an inhibitor of Met. It also inhibits EGFR, HER2, and HER4 (IC50s = 9.6, 18, and 40.3 nM, respectively). JNJ-26483327 (5 or 10 µM), in combination with trastuzumab, reduces HER2 phosphorylation in BT474 breast cancer cells. It decreases tumor volume when used in combination with trastuzumab in a BT474 mouse xenograft model when administered at a dose of 75 mg/kg twice per day. InChI: InChI=1S/C22H25BrN4O2/c1-27-8-4-3-5-9-29-21-11-17-19(12-20(21)28-2)24-14-25-22(17)26-18-10-16(23)7-6-15(18)13-27/h6-7,10-12,14H,3-5,8-9,13H2,1-2H3,(H,24,25,26) InChIKey: JXDYOSVKVSQGJM-UHFFFAOYSA-N SMILES: BrC1=CC=C2C(NC3=C4C=C(OCCCCCN(C2)C)C(OC)=CC4=NC=N3)=C1

Schlagworte:	17-bromo-1,8,9,10,11,12,13,14-octahydro-20-methoxy-13-methyl-4,6-ethenopyrimido[4,5-b][6,1,12]benzoxadiazacyclopentadecine
Hersteller:	Cayman Chemical
Hersteller-Nr:	44468

Eigenschaften

Anwendung:	Met inhibitor
MW:	457.37 D
Formel:	C22H25BrN4O2
Reinheit:	>98%
Format:	Solid

Datenbank Information

CAS :	807640-87-5\| Passende Produkte
KEGG ID :	K05099 \| Passende Produkte

Handhabung & Sicherheit

Lagerung:	-20°C
Versand:	+20°C (International: -20°C)
Signalwort:	Warning
GHS-Piktogramme:
H-Sätze:	H315, H319, H335
P-Sätze:	P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501