Zu "K05099" wurden 248 Artikel gefunden!
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Human Met ELISA Kit
Artikelnummer: ARG81446.96
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces...
| Schlagworte: | MET, EC=2.7.10.1, SF receptor, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
1.118,00 €
JNJ-26483327
Artikelnummer: Cay44468-1
JNJ-26483327 is an inhibitor of Met. It also inhibits EGFR, HER2, and HER4 (IC50s = 9.6, 18, and 40.3 nM, respectively). JNJ-26483327 (5 or 10 µM), in combination with trastuzumab, reduces HER2 phosphorylation in BT474 breast cancer cells. It decreases tumor volume when used in combination with trastuzumab in a...
| Schlagworte: | 17-bromo-1,8,9,10,11,12,13,14-octahydro-20-methoxy-13-methyl-4,6-ethenopyrimido[4,5-b][6,1,12]benzoxadiazacyclopentadecine |
| Anwendung: | Met inhibitor |
| CAS | 807640-87-5 |
| MW: | 457.37 D |
ab 209,00 €
HGF R/c-MET hFc Chimera, Human
Artikelnummer: GSC-Z05376-100
c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGF R), is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which...
| Schlagworte: | MET, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, Tyrosine-protein kinase Met, Hepatocyte growth factor... |
| Ursprungsart: | human |
| MW: | 32.5/95.9 kD |
ab 323,00 €
![HGF R/c-MET[Biotin], His & Avi, Human](https://www.biomol.com/media/image/68/8e/a7/GSC-Z04478-100_200x200.png "HGF R/c-MET[Biotin], His & Avi, Human")
HGF R/c-MET[Biotin], His & Avi, Human
Artikelnummer: GSC-Z04478-100
et, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGF R), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are...
| Schlagworte: | MET, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, Tyrosine-protein kinase Met, Hepatocyte growth factor... |
| Ursprungsart: | human |
| MW: | 32.5/72.1 kD |
ab 887,00 €
INCB 28060
Artikelnummer: Cay20056-5
INCB 28060 is an inhibitor of heptatocyte growth factor receptor (HGFR, also known as c-Met), potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM). It blocks cell proliferation and migration or induces apoptosis...
| Schlagworte: | Capmatinib, INC 280, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-benzamide |
| Anwendung: | c-MET inhibitor |
| CAS | 1029712-80-8 |
| MW: | 412.4 D |
ab 131,00 €
PHA-665752
Artikelnummer: Cay14703-1
The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor, have been implicated in the development and progression of several human cancers. PHA-665752 is an ATP-competitive, active-site inhibitor of the catalytic activity of c-Met kinase (Ki = 4 nM, IC50 = 9 nM). It exhibits >50-fold selectivity...
| Schlagworte: | (3Z)-5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-... |
| Anwendung: | ATP-competitive, active-site c-Met kinase inhibitor |
| CAS | 477575-56-7 |
| MW: | 641.6 D |
ab 73,00 €
Foretinib
Artikelnummer: Cay16249-1
Foretinib is a broad-spectrum tyrosine kinase (TK) inhibitor that targets members of the HGF and VEGF receptor TK families, as well as KIT, Flt-3, PDGFRbeta, and Tie-2, at nanomolar concentrations. It blocks HGF-induced Met phosphorylation and VEGF-induced ERK phosphorylation, preventing HGF-induced responses in...
| Schlagworte: | GSK1363089, XL880,... |
| Anwendung: | VEGFR2 / MET inhibitor |
| CAS | 849217-64-7 |
| MW: | 632.7 D |
ab 49,00 €
(R)-Crizotinib
Artikelnummer: Cay12087-50
(R)-Crizotinib is a dual inhibitor of c-Met and anaplastic lymphoma kinase (ALK, IC50s = 8 and 20 nM, respectively, in a cell-based assay). It is selective for c-Met and ALK over several other receptor- and non-receptor tyrosine kinases, including Ron, Tie2, Abl, LCK, and VEGFR2 (IC50s = 0.08, 0.448, 1.159, 2.741,...
| Schlagworte: | PF 2341066, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine |
| Anwendung: | c-Met /ALK inhibitor |
| CAS | 877399-52-5 |
| MW: | 450.3 D |
ab 130,00 €
AMG 337
Artikelnummer: Cay21333-1
AMG 337 is an orally active and selective inhibitor of c-Met kinase activity (IC50 = 1 nM) and adaptor protein Gab-1 phosphorylation, which subsequently blocks downstream PI3K and MAPK pathways. It has been shown to inhibit hepatocyte growth factor-mediated c-Met phosphorylation in PC3 cells (IC50 = 5 nM) and to...
| Schlagworte: | 6-[(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyr... |
| Anwendung: | c-Met inhibitor |
| CAS | 1173699-31-4 |
| MW: | 463.5 D |
ab 49,00 €
SGX523
Artikelnummer: Cay18093-25
The hepatocyte growth factor receptor c-Met commonly shows elevated activity in several forms of cancer. SGX523 is a potent, selective, ATP-competitive inhibitor that blocks the tyrosine kinase activity of c-Met with an IC50 value of 4 nM. It is over 1,000-fold selective for c-Met over a panel of other kinases....
| Schlagworte: | 6-[[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-quinoline |
| Anwendung: | c-Met inhibitor |
| CAS | 1022150-57-7 |
| MW: | 359.4 D |
ab 67,00 €
NPS 1034
Artikelnummer: Cay19627-1
NPS 1034 is a dual inhibitor of the receptor tyrosine kinase activities of MET (IC50 = 48 nM) and AXL (IC50 = 10.3 nM), receptors for hepatocyte growth factor and vitamin K-dependent proteins, respectively. It synergistically inhibits cell proliferation when used in combination with gefitinib (Cay-13166) or...
| Schlagworte: | 2-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-1H-py... |
| Anwendung: | MET inhibitor |
| CAS | 1221713-92-3 |
| MW: | 551.6 D |
ab 56,00 €
Glumetinib
Artikelnummer: Cay28952-1
Glumetinib is a potent inhibitor of c-Met (IC50 = 0.42 nM). It is greater than 2,400-fold selective for c-Met over a panel of 312 kinases. Glumetinib (0.001-1 µM) inhibits c-Met phosphorylation in and proliferation of MET-overexpressing EBC-1 lung and MKN45 gastric cancer cells. It inhibits NCI H441 cell motility...
| Schlagworte: | SCC244,... |
| Anwendung: | Potent c-Met inhibitor |
| CAS | 1642581-63-2 |
| MW: | 459.5 D |
ab 54,00 €