Zu "K05099" wurden 190 Artikel gefunden!
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XL092
Artikelnummer: Cay37749-25
XL092 is a multi-kinase inhibitor. It selectively inhibits the receptor tyrosine kinases (RTKs) MET, VEGFR2, Axl, and Mer (IC50s = 3, 15, 5.8, and 0.6 nM, respectively) over serine/threonine kinases for which it has no activity, but does inhibit 28 other RTKs with IC50 values ranging from 3 to 54 nM, as well as...
| Schlagworte: | Zanzalintinib,... |
| Anwendung: | Multi-kinase inhibitor |
| CAS | 2367004-54-2 |
| MW: | 528.5 D |
ab 105,00 €
Anti-Met
Artikelnummer: ELK-EA318.50
Met, a high affinity tyrosine kinase receptor for hepatocyte growth factor (HGF, also known as scatter factor) is a disulfide-linked heterodimer made of 45 kDa alpha- and 145 kDa beta-subunits. Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by...
| Schlagworte: | Anti-MET, EC=2.7.10.1, Anti-SF receptor, Anti-HGF receptor, Anti-HGF/SF receptor, Anti-Proto-oncogene c-Met, Anti-Scatter... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
169,00 €
Anti-Met Recombinant Monoclonal
Artikelnummer: A700-283
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces...
| Schlagworte: | Anti-MET, EC=2.7.10.1, Anti-SF receptor, Anti-HGF receptor, Anti-HGF/SF receptor, Anti-Proto-oncogene c-Met, Anti-Scatter... |
| Anwendung: | WB, IP, IHC, ICC, FC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 172,00 €
INCB 28060
Artikelnummer: Cay20056-5
INCB 28060 is an inhibitor of heptatocyte growth factor receptor (HGFR, also known as c-Met), potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM). It blocks cell proliferation and migration or induces apoptosis...
| Schlagworte: | Capmatinib, INC 280, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-benzamide |
| Anwendung: | c-MET inhibitor |
| CAS | 1029712-80-8 |
| MW: | 412.4 D |
ab 118,00 €
AMG 458
Artikelnummer: Cay36213-1
AMG 458 is an inhibitor of c-Met (Kis = 1.2, 1.1, 2.2, 4.1, 0.5, and 4.5 nM for wild-type c-Met, c-MetV1092I, c-MetD1228H, c-MetM1250T, c-MetH1094R, and c-MetY1230H, respectively). It inhibits c-Met phosphorylation in PC3 and CT26 cells (IC50s = 60 and 120 nM, respectively). AMG 458 (30 and 100 mg/kg) reduces tumor...
| Schlagworte: | 2,3-dihydro-1-(2-hydroxy-2-methylpropyl)-N-[5-[(7-methoxy-4-quinolinyl)oxy]-2-pyridinyl]-5-methyl-3-oxo-2-phenyl-1H-pyrazo... |
| Anwendung: | c-Met inhibitor |
| CAS | 913376-83-7 |
| MW: | 539.6 D |
ab 90,00 €
PHA-665752
Artikelnummer: Cay14703-1
The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor, have been implicated in the development and progression of several human cancers. PHA-665752 is an ATP-competitive, active-site inhibitor of the catalytic activity of c-Met kinase (Ki = 4 nM, IC50 = 9 nM). It exhibits >50-fold selectivity...
| Schlagworte: | (3Z)-5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-... |
| Anwendung: | ATP-competitive, active-site c-Met kinase inhibitor |
| CAS | 477575-56-7 |
| MW: | 641.6 D |
ab 66,00 €
Foretinib
Artikelnummer: Cay16249-1
Foretinib is a broad-spectrum tyrosine kinase (TK) inhibitor that targets members of the HGF and VEGF receptor TK families, as well as KIT, Flt-3, PDGFRbeta, and Tie-2, at nanomolar concentrations. It blocks HGF-induced Met phosphorylation and VEGF-induced ERK phosphorylation, preventing HGF-induced responses in...
| Schlagworte: | GSK1363089, XL880,... |
| Anwendung: | VEGFR2 / MET inhibitor |
| CAS | 849217-64-7 |
| MW: | 632.7 D |
ab 43,00 €
(R)-Crizotinib
Artikelnummer: Cay12087-50
(R)-Crizotinib is a dual inhibitor of c-Met and anaplastic lymphoma kinase (ALK, IC50s = 8 and 20 nM, respectively, in a cell-based assay). It is selective for c-Met and ALK over several other receptor- and non-receptor tyrosine kinases, including Ron, Tie2, Abl, LCK, and VEGFR2 (IC50s = 0.08, 0.448, 1.159, 2.741,...
| Schlagworte: | PF 2341066, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine |
| Anwendung: | c-Met /ALK inhibitor |
| CAS | 877399-52-5 |
| MW: | 450.3 D |
ab 117,00 €
AMG 337
Artikelnummer: Cay21333-1
AMG 337 is an orally active and selective inhibitor of c-Met kinase activity (IC50 = 1 nM) and adaptor protein Gab-1 phosphorylation, which subsequently blocks downstream PI3K and MAPK pathways. It has been shown to inhibit hepatocyte growth factor-mediated c-Met phosphorylation in PC3 cells (IC50 = 5 nM) and to...
| Schlagworte: | 6-[(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyr... |
| Anwendung: | c-Met inhibitor |
| CAS | 1173699-31-4 |
| MW: | 463.5 D |
ab 43,00 €
Anti-c-MET / HGFR, clone 14G9
Artikelnummer: 0212-100
| Schlagworte: | Anti-Met, Hepatocyte growth factor receptor, EC=2.7.10.1 |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
383,00 €
SGX523
Artikelnummer: Cay18093-25
The hepatocyte growth factor receptor c-Met commonly shows elevated activity in several forms of cancer. SGX523 is a potent, selective, ATP-competitive inhibitor that blocks the tyrosine kinase activity of c-Met with an IC50 value of 4 nM. It is over 1,000-fold selective for c-Met over a panel of other kinases....
| Schlagworte: | 6-[[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-quinoline |
| Anwendung: | c-Met inhibitor |
| CAS | 1022150-57-7 |
| MW: | 359.4 D |
ab 60,00 €
Glumetinib
Artikelnummer: Cay28952-1
Glumetinib is a potent inhibitor of c-Met (IC50 = 0.42 nM). It is greater than 2,400-fold selective for c-Met over a panel of 312 kinases. Glumetinib (0.001-1 µM) inhibits c-Met phosphorylation in and proliferation of MET-overexpressing EBC-1 lung and MKN45 gastric cancer cells. It inhibits NCI H441 cell motility...
| Schlagworte: | SCC244,... |
| Anwendung: | Potent c-Met inhibitor |
| CAS | 1642581-63-2 |
| MW: | 459.5 D |
ab 48,00 €