Zu "K05099" wurden 234 Artikel gefunden!
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Anti-MET (emibetuzumab biosimilar) mAb
Artikelnummer: DIM-BME100245.100
Research use only. ELISA 1:5000-10000, Flow Cyt 1:100. Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and...
| Schlagworte: | LA480, LY-2875358, LY2875358, Anti-MET, EC=2.7.10.1, Anti-SF receptor, Anti-HGF receptor, Anti-HGF/SF receptor,... |
| Anwendung: | ELISA, FC |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 118,00 €
BAY-474
Artikelnummer: Cay41451-1
BAY-474 is an inhibitor of c-Met (IC50 = 98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: N#CC1=C(C)NC(C)=C(C1C2=CC3=C(NN=C3C)C=C2)C#N. InChi Code:...
| Schlagworte: | 1,4-dihydro-2,6-dimethyl-4-(3-methyl-1H-indazol-5-yl)-3,5-pyridinedicarbonitrile |
| Anwendung: | c-Met inhibitor |
| CAS | 1033767-86-0 |
| MW: | 289.3 D |
ab 59,00 €
AMG-458
Artikelnummer: TGM-T6378-5mg
Description: AMG-458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells. Target: c-Met/HGFR. Smiles: COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1. References: Liu L, et al. J Med Chem, 2008, 51(13), 3688-3691.
| Schlagworte: | AMG 458 |
| Anwendung: | c-Met inhibitor |
| CAS | 913376-83-7 |
| MW: | 539.58 D |
ab 37,00 €
Capmatinib
Artikelnummer: TGM-T1963-100mg
Description: Capmatinib (INCB28060) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity. Target: Apoptosis, c-Met/HGFR. Smiles: CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1. References: Liu X, et al, Clin Cancer Res, 2011, 17(227). 7127-7138.
| Schlagworte: | NVP-INC280, INC-280, INCB28060 |
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1] (MET, HGFR) |
| CAS | 1029712-80-8 |
| MW: | 412.42 D |
ab 43,00 €
C-Met inhibitor D9
Artikelnummer: TGM-T67859-100mg
Description: C-Met inhibitor D9 is a c-Met kinase inhibitor. Target: c-Met/HGFR. Smiles: N(NC(CCC1=CC=CC=C1)=O)=C2C=3C(NC2=O)=CC=CC3. References: Liang Z, et al. Identification and synthesis of N'-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase. Bioorg Med Chem Lett. 2011 Jun 15,21(12):3749-54.
| Anwendung: | C-Met inhibitor |
| CAS | 299405-67-7 |
| MW: | 293.32 D |
ab 194,00 €
PHA-665752
Artikelnummer: TGM-T6128-100mg
Description: PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs. Target: VEGFR, FGFR, Autophagy, Bcr-Abl, c-Met/HGFR, Apoptosis. Smiles:...
| Schlagworte: | PHA 665752, PHA665752 |
| Anwendung: | ATP-competitive, active-site c-Met kinase inhibitor |
| CAS | 477575-56-7 |
| MW: | 641.61 D |
ab 60,00 €
SU11274
Artikelnummer: TGM-T6154-100mg
Description: SU11274 (Met Kinase Inhibitor)(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRbeta, EGFR or Tie2. Target: Apoptosis, c-Met/HGFR, CDK, Autophagy, VEGFR, FGFR. Smiles: C(=C\1/C=2C(NC1=O)=CC=C(S(N(C)C3=CC(Cl)=CC=C3)(=O)=O)C2)\C4=C(C)C(C(=O)N5CCN(C)CC5)=C(C)N4....
| Schlagworte: | PKI-SU11274, Met Kinase Inhibitor |
| Anwendung: | c-Met inhibitor |
| CAS | 658084-23-2 |
| MW: | 568.09 D |
ab 40,00 €
MK-2461
Artikelnummer: TGM-T6094-100mg
Description: MK-2461 is a novel inhibitor that targets multiple proteins and competitively binds to ATP sites, specifically inhibiting the activated c-Met protein with an average inhibitory concentration (IC50) of 2.5 nM. Target: c-Met/HGFR. Smiles: CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1....
| Schlagworte: | MK2461 |
| Anwendung: | c-MET inhibitor |
| CAS | 917879-39-1 |
| MW: | 495.55 D |
ab 48,00 €
c-Met inhibitor 1
Artikelnummer: TGM-T10655-100mg
Description: c-Met inhibitor 1 is a c-Met receptor signaling pathway inhibitor, used for the treatment of cancer including glioblastoma, gastric, and pancreatic cancer. Target: c-Met/HGFR. Smiles: Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4nn(C)cc4c3)n2n1. References: PCT Int. Appl. (2012), WO 2012015677 A1 20120202.
| Anwendung: | c-Met inhibitor |
| CAS | 1357072-61-7 |
| MW: | 362.41 D |
ab 77,00 €
CSF1R-IN-2
Artikelnummer: TGM-T13194-100mg
Description: CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively). Target: c-Fms, c-Met/HGFR, Src. Smiles: CCN1Cc2c(O[C@@H](C)CNC(=O)c3c(N)nn4ccc1nc34)ccc(F)c2C#N. References: WO 2019023417 A1.
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1] (MET, HGFR) |
| CAS | 2271119-26-5 |
| MW: | 409.42 D |
ab 40,00 €
Glesatinib
Artikelnummer: TGM-T15384-100mg
Description: Glesatinib is an orally active and potent dual inhibitor of MET/SMO. Glesatinib is also a tyrosine kinase inhibitor. It antagonizes P-glycoprotein mediated multidrug resistance (MDR) in NSCLC. Target: c-Met/HGFR. Smiles:...
| Schlagworte: | MGCD265 |
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1] (MET, HGFR) |
| CAS | 936694-12-1 |
| MW: | 619.7 D |
ab 1.671,00 €
AMG-337
Artikelnummer: TGM-T3209-100mg
Description: AMG-337 is an effective and highly specific ATP-competitive MET kinase inhibitor. In enzymatic assays, AMG-337(AMG337) inhibits MET kinase activity (IC50: < 5 nM). Target: c-Met/HGFR. Smiles: COCCOc1cnc2ccn([C@H](C)c3nnc4c(F)cc(cn34)-c3cnn(C)c3)c(=O)c2c1. References: Hughes PE, et al. Mol Cancer Ther....
| Schlagworte: | AMG337 |
| Anwendung: | c-Met inhibitor |
| CAS | 1173699-31-4 |
| MW: | 463.46 D |
ab 34,00 €