JHU083

JHU083 is a prodrug form of the glutaminase inhibitor 6-diazo-5-oxo-L-nor-leucine (Cay-17580). It decreases tumor volume, increases tumor microenvironment (TME) levels of Tnf-secreting macrophages, and increases survival in a B6CaP murine prostate cancer model. JHU083 increases tumor infiltration by Cd8+ T cells in a UN-SCC680 murine lung squamous cell carcinoma model. It also reduces granuloma area and lung weight and increases survival in M. tuberculosis-infected mice.. Solulibility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml: DMSO: Sparingly soluble: 1-10 mg/ml.