Zu "K01425" wurden 116 Artikel gefunden!
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Anti-Glutaminase / GLS
Artikelnummer: NSJ-F54260-0.05ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Sahai (1983) demonstrated phosphate-activated glutaminase (EC 3.5.1.2) in human platelets. It is the major enzyme yielding glutamate from glutamine. Significance of the enzyme derives from its possible implication in behavior disturbances in which glutamate acts as a...
| Schlagworte: | Anti-GLS, Anti-K-glutaminase, Anti-L-glutamine amidohydrolase, Anti-Glutaminase kidney isoform, mitochondrial, Glutaminase... |
| Anwendung: | WB, IHC (paraffin), FC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 361,00 €
Anti-Recombinant Glutaminase C, clone 8D10
Artikelnummer: E-AN301062L.100
This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism,...
| Schlagworte: | Anti-GLS, Anti-K-glutaminase, Anti-L-glutamine amidohydrolase, Anti-Glutaminase kidney isoform, mitochondrial, Recombinant... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
CB-839
Artikelnummer: Cay22038-5
CB-839 is an orally bioavailable noncompetitive inhibitor of the glutaminase 1 (GLS1) splice variants, kidney-type (KGA) and glutaminase C (GAC), which convert glutamine into glutamate. CB-839 inhibits human recombinant GAC with IC50 values of less than 50 nM, varying based on the length of preincubation. It...
| Schlagworte: | GLS1 Inhibitor III,... |
| Anwendung: | Glutaminase inhibitor |
| CAS | 1439399-58-2 |
| MW: | 571.6 D |
ab 88,00 €
BPTES
Artikelnummer: Cay19284-5
BPTES is an allosteric inhibitor of kidney-type glutaminase 1 (GLS1, IC50 = 3.3 µM) that drives the formation of inactive GLS1 tetramers. It is selective for GLS1 over GLS2, glutamate dehydrogenase, and gamma-glutamyl transpeptidase. BPTES decreases glutaminase activity and reduces proliferation of aerobic P493...
| Schlagworte: | N,N'-[thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bis-benzeneacetamide |
| Anwendung: | GLS inhibitor |
| CAS | 314045-39-1 |
| MW: | 524.7 D |
ab 38,00 €
Glutaminase-IN-1
Artikelnummer: Cay42339-1
An inhibitor of GLS1 (IC50 = 1 nM), selective for GLS1 over GDH (IC50 = >13 µM), inhibits the proliferation of A549, H22, Caki-1, and HCT116 cancer cells (IC50s = 0.017, 6.78, 0.019, and 0.009 µM, respectively), induces ROS production in A549 cells at 10 µM, decreases tumor weight in an HCT116 mouse xenograft model...
| Schlagworte: | GLS Inhibitor 1, GLS-IN-1, Glutaminase Inhibitor 1,... |
| Anwendung: | GLS1 inhibitor |
| CAS | 2247127-79-1 |
| MW: | 618.47 D |
ab 44,00 €
Glutaminase-IN-3
Artikelnummer: Cay42325-100
An inhibitor of GAC (IC50 = 0.24 µM), inhibits the proliferation of PC3 and LNCaP prostate cancer cells (IC50s = 6.14 and 2.13 µM, respectively) and non-cancerous CCD-1072Sk fibroblasts (IC50 = 15.39 µM). Formulation: A solid. InChI:...
| Schlagworte: | Glutaminase Inhibitor 3, N-[6-[4-(5-amino-1,3,4-thiadiazol-2-yl)butyl]-3-pyridazinyl]-3-(trifluoromethoxy)-benzeneacetamide |
| Anwendung: | GAC inhibitor |
| CAS | 1439399-45-7 |
| MW: | 452.5 D |
ab 169,00 €
UPGL00004
Artikelnummer: Cay42323-10
A GAC inhibitor (IC50 = 29 nM), reduces the proliferation of MDA-MB-231, Hs 578T, and TSE cells (IC50s = 70, 129, and 262 nM, respectively), inhibits replication of SARS-CoV-2 and HCoV-OC43 in Vero and primary HBECs, respectively, at 0.1 µM. Formulation: A solid. InChI:...
| Schlagworte: | UP4, N-[5-[4-[[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]amino]-1-piperidinyl]-1,3,4-thiadiazol-2-yl]-benzeneacetamide |
| Anwendung: | Glutaminase C (GAC) inhibitor |
| CAS | 1890169-95-5 |
| MW: | 534.66 D |
ab 118,00 €
JHU083
Artikelnummer: Cay40642-1
JHU083 is a prodrug form of the glutaminase inhibitor 6-diazo-5-oxo-L-nor-leucine (Cay-17580). It decreases tumor volume, increases tumor microenvironment (TME) levels of Tnf-secreting macrophages, and increases survival in a B6CaP murine prostate cancer model. JHU083 increases tumor infiltration by Cd8+ T cells in...
| Schlagworte: | L-leucyl-6-diazo-5-oxo-L-norleucine, ethyl ester |
| Anwendung: | Glutaminase inhibitor prodrug |
| CAS | 1998725-11-3 |
| MW: | 312.36 D |
ab 201,00 €
Glutaminase Activity Assay Kit
Artikelnummer: Cay702690-96
Cayman's Glutaminase Activity Assay Kit provides a convenient method of detecting glutaminase activity in cell lysates and tissue homogenates. Measurement of glutaminase activity is carried out by the Glutamine/Glutamate Developer Enzyme Mix, which detects levels of glutamate produced by glutaminase in the presence...
| Anwendung: | Glutaminase activity detection |
589,00 €
Glutaminase Inhibitor Compound 968
Artikelnummer: Cay17199-5
Glutaminase inhibitor compound 968 is a cell-permeable, reversible inhibitor of a mitochondrial glutaminase splice variant, glutaminase C (IC50 = ~2.5 µM), which is commonly found in cancer cells. Through this action, glutaminase inhibitor compound 968 blocks transformation induced by Rho GTPases and inhibits the...
| Schlagworte: | 5-[3-bromo-4-(dimethylamino)phenyl]-2,3,5,6-tetrahydro-2,2-dimethyl-benzo[a]phenanthridin-4(1H)-one |
| Anwendung: | Glutaminase inhibitor |
| CAS | 311795-38-7 |
| MW: | 475.4 D |
ab 49,00 €
Glutaminase Assay Kit (Colorimetric)
Artikelnummer: ARG82767.96
This Glutaminase Assay Kit (Colorimetric) is a detection kit for the quantification of Glutaminase activity in cells, bacteria and tissue samples. Protein function: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates...
| Schlagworte: | GLS, GLS1 |
| Anwendung: | FA |
| Spezies-Reaktivität: | broad |
863,00 €
BPTES
Artikelnummer: AG-CR1-3690-M005
Selective, allosteric non-competitive inhibitor of glutaminase 1 (GLS1), selective for GLS1 over GLS2, glutamate dehydrogenase, and gamma-glutamyl transpeptidase, consequently inhibiting glutaminolysis. Useful agent for immunometabolism research. Glutaminase converts glutamine to glutamate, which is an important...
| Schlagworte: | Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide |
| Anwendung: | Selective, allosteric non-competitive glutaminase 1 (GLS1) inhibitor |
| CAS | 314045-39-1 |
| MW: | 524.7 D |
ab 33,00 €