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JHU-083
Artikelnummer: TGM-T15613-100mg
Description: JHU-083 is a selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells. JHU-083 also experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals. Target: Others. Smiles: CCOC(=O)[C@H](CCC(=O)C=[N+]=[N-])NC(=O)[C@@H](N)CC(C)C....
| CAS | 1998725-11-3 |
| MW: | 312.37 D |
ab 1.383,00 €
JHU083
Artikelnummer: Cay40642-1
JHU083 is a prodrug form of the glutaminase inhibitor 6-diazo-5-oxo-L-nor-leucine (Cay-17580). It decreases tumor volume, increases tumor microenvironment (TME) levels of Tnf-secreting macrophages, and increases survival in a B6CaP murine prostate cancer model. JHU083 increases tumor infiltration by Cd8+ T cells in...
| Schlagworte: | L-leucyl-6-diazo-5-oxo-L-norleucine, ethyl ester |
| Anwendung: | Glutaminase inhibitor prodrug |
| CAS | 1998725-11-3 |
| MW: | 312.36 D |
ab 208,00 €
