Itopride (hydrochloride)

Itopride is an inhibitor of acetylcholinesterase (AChE, IC50 = 1.6 µM for rat stomach enzyme) and a prokinetic agent. It induces contractions in isolated rabbit duodenum when used at concentrations ranging from 1 to 100 µM and enhances ACh-induced contractions in isolated guinea pig stomach circular muscle strips. Itopride (100 mg/kg) enhances normal gastric antral motility and improves gastric antral hypomotility and delayed gastric emptying induced by clonidine (Cay-15949) in rats. Formulations containing itopride have been used in the treatment of functional dyspepsia.Formal Name: N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy-benzamide, monohydrochloride. CAS Number: 122892-31-3. Molecular Formula: C20H26N2O4 . HCl. Formula Weight: 394.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 213, 259 nm. SMILES: COC1=C(OC)C=CC(C(NCC2=CC=C(OCCN(C)C)C=C2)=O)=C1.Cl. InChi Code: InChI=1S/C20H26N2O4.ClH/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4,/h5-10,13H,11-12,14H2,1-4H3,(H,21,23),1H. InChi Key: ZTOUXLLIPWWHSR-UHFFFAOYSA-N.