IC261

IC261 is a reversible, ATP-competitive inhibitor of casein kinase 1 (CK1) that inhibits CK1delta and CK1? (IC50 = ~1 µM for both), as well as CK1alpha (IC50 = 16 µM). It is at least 100-fold less effective against PKA, p34cdc2, and p55fyn. IC 261, at 1 µM, inhibits cytokinesis in primary mouse embryo fibroblasts. IC261 is used to elucidate the role of CK1 in cells and in whole organisms.Formal Name: 1,3-dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one. CAS Number: 186611-52-9. Synonyms: SU5607. Molecular Formula: C18H17NO4. Formula Weight: 311.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 255, 358 nm. SMILES: COC1=C(/C=C2C(NC3=C/2C=CC=C3)=O)C(OC)=CC(OC)=C1. InChi Code: InChI=1S/C18H17NO4/c1-21-11-8-16(22-2)14(17(9-11)23-3)10-13-12-6-4-5-7-15(12)19-18(13)20/h4-10H,1-3H3,(H,19,20)/b13-10+. InChi Key: JBJYTZXCZDNOJW-JLHYYAGUSA-N.