Iberin

Iberin is a natural isothiocyanate found in cruciferous plants. When introduced into the daily diet of rats or added to rat hepatocytes (40 µM), it induces the expression of phase II detoxification enzymes, including quinone reductase and glutathione S-transferase. In addition, iberin activates the nuclear factor E2-related protein Nrf2, which promotes the expression of antioxidant and phase II genes. Iberin also induces the apoptosis of some cancer cell lines. Interestingly, iberin also acts as a quorum sensing inhibitor, blocking acyl-homoserine lactone signaling in P. aeruginosa without affecting growth (IC50 = 31-62 µM).InChI: InChI=1S/C5H9NOS2/c1-9(7)4-2-3-6-5-8/h2-4H2,1H3 InChIKey: LELAOEBVZLPXAZ-UHFFFAOYSA-N SMILES: CS(CCCN=C=S)=O