Zu "K05638" wurden 130 Artikel gefunden!
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Anti-NRF2 / Nuclear factor erythroid 2-related factor 2 /...
Artikelnummer: NSJ-FY13169
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. NRF2 antibody detects Nuclear factor erythroid 2-related factor 2, a transcription factor that regulates antioxidant defense and cellular detoxification. The UniProt recommended name is Nuclear factor erythroid 2-related factor 2 (NFE2L2)....
| Schlagworte: | Anti-NFE2L2, Anti-Nuclear factor, erythroid derived 2, like 2, Anti-Nuclear factor erythroid 2-related factor 2, NRF2... |
| Anwendung: | ELISA, FC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Nrf2 Transcription Factor Assay Kit
Artikelnummer: Cay600590-96
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that plays a key role in maintaining redox homeostasis via its interaction with a cysteine-rich protein Kelch-like ECH-associated protein 1 (Keap1). In resting cells, Nrf2 and Keap1 form a tight complex, which is targeted for degradation by...
| Schlagworte: | GABPA, HEBP1, NF-E2-related factor 2, Nuclear Factor Erythroid 2-related factor 2 |
| Anwendung: | DNA binding assay |
732,00 €
Glucoraphanin (potassium salt)
Artikelnummer: Cay10009445-1
Glucoraphanin is a natural glycoinsolate found in cruciferous vegetables, including broccoli. It is converted to the isothiocyanate sulforaphane by the enzyme myrosinase. Sulforaphane has powerful antioxidant, anti-inflammatory, and anti-carcinogenic effects. It acts by activating nuclear factor erythroid 2-related...
| Schlagworte: | 4-Methylsulfinylbutyl Glucosinolate, Sulforaphane Glucosinolate,... |
| Anwendung: | Nrf2 activator precursor, Chemopreventive agent |
| MW: | 436,5 D |
ab 223,00 €
L-Sulforaphane
Artikelnummer: Cay14797-10
L-Sulforaphane is an isothiocyanate derived from the natural compound glucoraphanin, which is abundant in cruciferous vegetables, including broccoli. It has powerful antioxidant, anti-inflammatory, and anti-carcinogenic effects. L-Sulforaphane, at 40 µM, activates nuclear factor erythroid 2-related factor 2- (Nrf2)...
| Schlagworte: | (R)-Sulforaphane, 1-isothiocyanato-4-[(R)-methylsulfinyl]-butane |
| Anwendung: | Nrf2 activator, Chemopreventive agent |
| CAS | 142825-10-3 |
| MW: | 177.3 D |
ab 68,00 €
![[D-Asp3]-Microcystin-LR](https://www.biomol.com/media/image/06/d9/ec/Cay43503-30_200x200.png "[D-Asp3]-Microcystin-LR")
[D-Asp3]-Microcystin-LR
Artikelnummer: Cay43503-30
[D-Asp3]-Microcystin-LR is a cyanotoxin that has been found in Anabaena and an activator of nuclear factor erythroid 2-related factor 2 (Nrf2). It induces Nrf2 activation in HepG2 cells when used at concentrations ranging from 0.3-3 µM. InChI:...
| Schlagworte: | [D-Asp3]-MC-LR, [D-Asp3]-Cyanoginosin-LR,... |
| Anwendung: | Cyanotoxin, Nrf2 activator |
| CAS | 120011-66-7 |
| MW: | 981,16 D |
444,00 €
4-octyl Itaconate
Artikelnummer: Cay25374-25
4-octyl Itaconate is a prodrug form of itaconate, an endogenous cellular metabolite produced via decarboxylation of cis-aconitate by the enzyme encoded by IRG1. It is hydrolyzed to itaconate by esterases in C2C12 cells and LPS-activated mouse macrophages where it acts as a regulator of macrophage function with...
| Schlagworte: | 2-methylene-butanedioic acid, 4-octyl ester |
| Anwendung: | Prodrug, Nrf2 stabilization |
| CAS | 3133-16-2 |
| MW: | 242.3 D |
ab 68,00 €
R-Sulforaphane
Artikelnummer: LKT-S8046.10
A chiral natural product from broccoli. Also an inducer of phase II enzymes.
| Schlagworte: | L-Sulforaphane |
| Anwendung: | Chemopreventive agent |
| CAS | 142825-10-3 |
| MW: | 177,29 D |
ab 481,00 €
CDDO methyl ester
Artikelnummer: Cay11883-5
The synthetic oleanane triterpenoid CDDO (Cay-81035) is a Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. The C-28 methyl ester of CDDO (CDDO methyl ester) blocks the cellular synthesis of inducible nitric oxide synthase (iNOS) and inducible COX-2 in...
| Schlagworte: | Bardoxolone methyl, NSC 713200, RTA 402, TP-155, 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid, methyl ester |
| Anwendung: | Apoptosis inducer |
| CAS | 218600-53-4 |
| MW: | 505.7 D |
ab 87,00 €
(E)-3-(2-Fluorophenyl)-N-(1H-indol-5-yl)acrylamide
Artikelnummer: Cay43022-1
(E)-3-(2-Fluorophenyl)-N-(1H-indol-5-yl)acrylamide is an inhibitor of monoamine oxidase B (MAO-B) and an inducer of nuclear factor erythroid 2-related factor 2 (Nrf2). It inhibits MAO-B (IC50 = 3. µM) and increases levels of Nrf2 in a reporter assay using AREc32 cells (IC50 = 0. µM)....
| Schlagworte: | MAO-B inhibitor and NRF2 Inducers Compound 11 |
| Anwendung: | MAO-B inhibitor / Nrf2 inducer |
| MW: | 280.3 D |
ab 44,00 €
ARE Reporter Kit (Nrf2 Antioxidant Pathway )
Artikelnummer: BPS-60514
The ARE Reporter kit is designed for monitoring the activity of the Nrf2 antioxidant pathway in cultured cells. The kit contains a transfection-ready ARE luciferase reporter vector, which is an Nrf2 pathway-responsive reporter. This reporter contains a firefly luciferase gene under the control of multimerized ARE...
| Schlagworte: | HEBP1, Nrf-2, NFE2-related factor 2, NF-E2-related factor 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor,... |
| Anwendung: | Nrf2 pathway activity studies, activator/inhibitor screening |
1.027,00 €
Nrf2 (Human) Reporter Assay System
Artikelnummer: IB-IB10001-32
Protein function: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating...
| Schlagworte: | NRF2, HEBP1, NFE2L2, NFE2-related factor 2, NF-E2-related factor 2, Nuclear factor erythroid 2-related factor 2, Nuclear... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €
ML-334
Artikelnummer: Cay31439-1
ML-334 is an inhibitor of the protein-protein interaction between the transcription factor Nrf2 and its inhibitor Keap1. It binds to the Keap1 Kelch domain (IC50 = 1 µM) to induce dissociation and nuclear translocation of Nrf2 and activation of the antioxidant response element (ARE) in a cell-based assay (EC50 = 12...
| Schlagworte: | LH601, (1S,2R)-2-[[(1S... |
| Anwendung: | Nrf2-Keap1 protein-protein interaction inhibitor |
| CAS | 1432500-66-7 |
| MW: | 446.5 D |
ab 56,00 €