HAMNO

HAMNO is a small molecule inhibitor of replication protein A (RPA). It selectively binds to and inhibits DNA binding domain F (DBD-F) on RPA70 when used at concentrations up to 100 µM. HAMNO inhibits etoposide-induced autophosphorylation of ATR kinase and subsequent phosphorylation of RPA32 in UMSCC38 cells when used at concentrations of 10 and 20 µM. HAMNO (1 mg/kg), in combination with etoposide (Cay-12092), reduces tumor growth in UMSCC11B and UMSCC38 mouse xenograft models.Formal Name: 1-[[(2-hydroxyphenyl)amino]methylene]-2(1H)-naphthalenone. CAS Number: 138736-73-9. Molecular Formula: C17H13NO2. Formula Weight: 263.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:30): 0.25 mg/ml. lambdamax: 211, 235, 263, 321, 448, 472 nm. SMILES: O=C1/C(C2=CC=CC=C2C=C1)=C\NC3=C(O)C=CC=C3. InChi Code: InChI=1S/C17H13NO2/c19-16-10-9-12-5-1-2-6-13(12)14(16)11-18-15-7-3-4-8-17(15)20/h1-11,18,20H/b14-11-. InChi Key: NADCEWZYITXLKJ-KAMYIIQDSA-N.