HA-130

HA-130 is a reversible inhibitor of autotaxin, completely blocking the hydrolysis of the substrate bis-pNPP with an IC50 value of 28 nM. It does not affect the activity of any proteasomal protease or related enzymes. HA-130 rapidly decreases plasma lysophosphatidic acid levels in mice when given intravenously (1 nM/g). HA-130 has been used to investigate the role of autotaxin in cells and animals.Formal Name: B-[3-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid. CAS Number: 1229652-21-4. Molecular Formula: C24H19BFNO5S. Formula Weight: 463.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/mL, DMSO: 5 mg/mL, Ethanol: 0.5 mg/mL. lambdamax: 239, 348 nm. SMILES: FC1=CC=C(CN2C(/C(SC2=O)=C/C3=CC=C(OCC4=CC=CC(B(O)O)=C4)C=C3)=O)C=C1. InChi Code: InChI=1S/C24H19BFNO5S/c26-20-8-4-17(5-9-20)14-27-23(28)22(33-24(27)29)13-16-6-10-21(11-7-16)32-15-18-2-1-3-19(12-18)25(30)31/h1-13,30-31H,14-15H2/b22-13-. InChi Key: VTNKMYWFWQTEHE-XKZIYDEJSA-N.