Zu "K01122" wurden 92 Artikel gefunden!
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PF-8380
Artikelnummer: Cay12018-25
Autotaxin converts lysophosphatidylcholine to lysophosphatidic acid (LPA), which can mediate changes in cell proliferation, angiogenesis, and cytokine secretion. PF-8380 is a potent inhibitor of autotaxin (IC50 = 2.8 nM in an enzyme assay), the enzyme that converts lysophosphatidylcholine to lysophosphatidic acid...
| Schlagworte: | 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-(3,5-dichlorophenyl)methyl ester-1-piperazinecarboxylic acid |
| Anwendung: | Autotaxin Inhibitor |
| CAS | 1144035-53-9 |
| MW: | 478.3 D |
ab 72,00 €
Human ENPP2 ELISA Kit
Artikelnummer: ARG81621.96
Protein function: Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:15769751, PubMed:26371182, PubMed:27754931). Major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:27754931). Also can act on sphingosylphosphorylcholine...
| Schlagworte: | ENPP2, E-NPP 2, LysoPLD, Autotaxin, Extracellular lysophospholipase D, Ectonucleotide pyrophosphatase/phosphodiesterase... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
1.151,00 €
ENPP-2/Autotaxin, His, Human
Artikelnummer: GSC-Z05241-100
Ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) also known as Autotaxin, is a secreted lysophospholipase D, which hydrolyzes lysophosphatidylcholine (LPC) into Lysophosphatidic acid (LPA). ENPP2 is an essential protein for normal development and its altered expression is associated with various human...
| Schlagworte: | ENPP2, Autotaxin, Extracellular lysophospholipase D, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
| Ursprungsart: | human |
| MW: | 94.8 kD |
ab 524,00 €
ENPP-2/Autotaxin, His, Mouse
Artikelnummer: GSC-Z06098-100
Ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) also known as Autotaxin, is a secreted lysophospholipase D, which hydrolyzes lysophosphatidylcholine (LPC) into Lysophosphatidic acid (LPA). ENPP2 is an essential protein for normal development and its altered expression is associated with various human...
| Schlagworte: | Enpp2, Autotaxin, Extracellular lysophospholipase D, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
| Ursprungsart: | mouse |
| MW: | 94.7 kD |
ab 524,00 €
S32826
Artikelnummer: Cay13664-5
Autotaxin is a lysophospholipase D, cleaving lysophosphatidylcholine to produce choline and lysophosphatidic acid (LPA). S32826 is a potent and selective inhibitor of autotaxin, inhibiting recombinant autotaxin beta with an IC50 of 8.8 nM. It shows similar effectiveness against the three known autotaxin isoforms...
| Schlagworte: | P-[[4-[(1-oxotetradecyl)amino]phenyl]methyl]-phosphonic acid |
| Anwendung: | Autotaxin inhbitor |
| CAS | 1096770-84-1 |
| MW: | 397.5 D |
ab 57,00 €
Autotaxin Inhibitor Screening Assay Kit
Artikelnummer: Cay700580-96
Autotaxin (ATX, Ectonucleotide Pyrophosphatase/Phosphodiesterase-2, ENPP-2, Lysophospholipase D) is a secreted lysophospholipase D that catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to generate lysophosphatidic acid (LPA). LPA is a lipid mediator that activates G protein-coupled receptors and induces a...
| Schlagworte: | ATX Inhibitor Screening Assay Kit |
| Anwendung: | ATX inhibitor screening |
| Spezies-Reaktivität: | human |
776,00 €
Oleoyl 3-carbacyclic Phosphatidic Acid
Artikelnummer: Cay10010299-1
Cyclic phosphatidic acids (cPAs) are naturally occurring analogs of lysophosphatidic acid (LPA) in which the sn-2 hydroxy group forms a 5-membered ring with the sn-3 phosphate. Carba-derivatives of cPA (ccPA) are modified at the sn-2 (2-ccPA) or sn-3 (3-ccPA) linkage, preventing the opening of cPA to produce...
| Schlagworte: | 3-ccPA 18:1, (9Z)-9-octadecenoic acid, (2-hydroxy-2-oxido-1,2-oxaphospholan-5-yl)methyl ester |
| Anwendung: | Cyclic LPA analog |
| CAS | 779333-58-3 |
| MW: | 416.5 D |
ab 116,00 €
Human ENPP2 (Ectonucleotide...
Artikelnummer: ELK-ELK3185.96
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ENPP2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ENPP2. Next,...
| Schlagworte: | ENPP2, E-NPP 2, LysoPLD, Autotaxin, Extracellular lysophospholipase D, Ectonucleotide pyrophosphatase/phosphodiesterase... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 374,00 €
HA-130
Artikelnummer: Cay10498-5
HA-130 is a reversible inhibitor of autotaxin, completely blocking the hydrolysis of the substrate bis-pNPP with an IC50 value of 28 nM. It does not affect the activity of any proteasomal protease or related enzymes. HA-130 rapidly decreases plasma lysophosphatidic acid levels in mice when given intravenously (1...
| Schlagworte: | B-[3-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid |
| Anwendung: | Reversible autotaxin inhibitor |
| CAS | 1229652-21-4 |
| MW: | 463.3 D |
ab 108,00 €
Autotaxin (human, recombinant)
Artikelnummer: Cay10803-100
Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a secreted lysophospholipase D (lysoPLD) that hydrolyzes lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), which has roles in cell proliferation, survival, and migration. It is synthesized as a zymogen and is composed...
| Schlagworte: | ENPP2, E-NPP 2, LysoPLD, E-NPP 2, LysoPLD, Autotaxin, Autotaxin, Extracellular lysophospholipase D, Extracellular... |
| Anwendung: | Enzyme activity |
| Exprimiert in: | Insect cells |
732,00 €
Mouse ENPP2 / Autotaxin ELISA Kit
Artikelnummer: G-MOFI00371.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
698,00 €
GLPG1690
Artikelnummer: Cay25498-5
GLP1690 is a potent inhibitor of autotaxin (Ki = 15 nM). It inhibits the production of lysophosphatidic acid (LPA) in mouse, rat, and human plasma (IC50s = 418, 542, and 242 nM, respectively). GLPG1690 (30 mg/kg) reduces extracellular matrix deposition in the lung as well as LPA 18:2 levels in bronchoalveolar lavage...
| Schlagworte: | 2-[[2-ethyl-6-[4-[2-(3-hydroxy-1-azetidinyl)-2-oxoethyl]-1-piperazinyl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-... |
| Anwendung: | Potent autotaxin inhibitor |
| CAS | 1628260-79-6 |
| MW: | 588.7 D |
ab 139,00 €