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Zu "K01122" wurden 51 Artikel gefunden!
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Artikelnummer: Cay12018-25
Autotaxin converts lysophosphatidylcholine to lysophosphatidic acid (LPA), which can mediate changes in cell proliferation, angiogenesis, and cytokine secretion. PF-8380 is a potent inhibitor of autotaxin (IC50 = 2.8 nM in an enzyme assay), the enzyme that converts lysophosphatidylcholine to lysophosphatidic acid...
Schlagworte: | 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-(3,5-dichlorophenyl)methyl ester-1-piperazinecarboxylic acid |
Anwendung: | Autotaxin Inhibitor |
CAS | 1144035-53-9 |
MW: | 478.3 D |
ab 65,00 €
Artikelnummer: ELK-ELK3185.96
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ENPP2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ENPP2. Next,...
Schlagworte: | ENPP2, E-NPP 2, LysoPLD, Autotaxin, Extracellular lysophospholipase D, Ectonucleotide pyrophosphatase/phosphodiesterase... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: ELK-ELK7406.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat ENPP2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat ENPP2. Next,...
Schlagworte: | Atx, Enpp2, E-NPP 2, LysoPLD, Autotaxin, Extracellular lysophospholipase D, Ectonucleotide... |
Anwendung: | ELISA |
Spezies-Reaktivität: | rat |
ab 365,00 €
Artikelnummer: ELK-ELK7491.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse ENPP2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse ENPP2. Next,...
Schlagworte: | Enpp2, Npps2, E-NPP 2, LysoPLD, Autotaxin, Extracellular lysophospholipase D, Ectonucleotide... |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
ab 365,00 €
Artikelnummer: Cay38789-1
Cudetaxestat is an inhibitor of autotaxin (IC50 = =0.5 µM), also known as ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2). It reduces migration of MDA-MB-435 melanoma cells (IC50 = 15 nM). Cudetaxestat reduces blood glucose levels in a glucose tolerance test, as well as baseline blood...
Schlagworte: | 3-[[2,6-dichloro-7-fluoro-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl]thio]-2-fluoro-benzoic acid |
Anwendung: | Autotaxin (ENPP2) inhibitor |
CAS | 1782070-21-6 |
MW: | 482.3 D |
ab 109,00 €
Artikelnummer: Cay13664-5
Autotaxin is a lysophospholipase D, cleaving lysophosphatidylcholine to produce choline and lysophosphatidic acid (LPA). S32826 is a potent and selective inhibitor of autotaxin, inhibiting recombinant autotaxin beta with an IC50 of 8.8 nM. It shows similar effectiveness against the three known autotaxin isoforms...
Schlagworte: | P-[[4-[(1-oxotetradecyl)amino]phenyl]methyl]-phosphonic acid |
Anwendung: | Autotaxin inhbitor |
CAS | 1096770-84-1 |
MW: | 397.5 D |
ab 52,00 €
Artikelnummer: Cay700580-96
Autotaxin (ATX, Ectonucleotide Pyrophosphatase/Phosphodiesterase-2, ENPP-2, Lysophospholipase D) is a secreted lysophospholipase D that catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to generate lysophosphatidic acid (LPA). LPA is a lipid mediator that activates G protein-coupled receptors and induces a...
Schlagworte: | ATX Inhibitor Screening Assay Kit |
Anwendung: | ATX inhibitor screening |
Spezies-Reaktivität: | human |
700,00 €
Artikelnummer: Cay10010299-1
Cyclic phosphatidic acids (cPAs) are naturally occurring analogs of lysophosphatidic acid (LPA) in which the sn-2 hydroxy group forms a 5-membered ring with the sn-3 phosphate. Carba-derivatives of cPA (ccPA) are modified at the sn-2 (2-ccPA) or sn-3 (3-ccPA) linkage, preventing the opening of cPA to produce...
Schlagworte: | 3-ccPA 18:1, (9Z)-9-octadecenoic acid, (2-hydroxy-2-oxido-1,2-oxaphospholan-5-yl)methyl ester |
Anwendung: | Cyclic LPA analog |
CAS | 779333-58-3 |
MW: | 416.5 D |
ab 102,00 €
Artikelnummer: Cay10498-5
HA-130 is a reversible inhibitor of autotaxin, completely blocking the hydrolysis of the substrate bis-pNPP with an IC50 value of 28 nM. It does not affect the activity of any proteasomal protease or related enzymes. HA-130 rapidly decreases plasma lysophosphatidic acid levels in mice when given intravenously (1...
Schlagworte: | B-[3-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid |
Anwendung: | Reversible autotaxin inhibitor |
CAS | 1229652-21-4 |
MW: | 463.3 D |
ab 97,00 €
Artikelnummer: Cay10803-100
Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a secreted lysophospholipase D (lysoPLD) that hydrolyzes lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), which has roles in cell proliferation, survival, and migration. It is synthesized as a zymogen and is composed...
Schlagworte: | ENPP2, E-NPP 2, LysoPLD, E-NPP 2, LysoPLD, Autotaxin, Autotaxin, Extracellular lysophospholipase D, Extracellular... |
Anwendung: | Enzyme activity |
Exprimiert in: | Insect cells |
661,00 €
Artikelnummer: G-MOFI00371.96
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
694,00 €
Artikelnummer: Cay25498-5
GLP1690 is a potent inhibitor of autotaxin (Ki = 15 nM). It inhibits the production of lysophosphatidic acid (LPA) in mouse, rat, and human plasma (IC50s = 418, 542, and 242 nM, respectively). GLPG1690 (30 mg/kg) reduces extracellular matrix deposition in the lung as well as LPA 18:2 levels in bronchoalveolar lavage...
Schlagworte: | 2-[[2-ethyl-6-[4-[2-(3-hydroxy-1-azetidinyl)-2-oxoethyl]-1-piperazinyl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-... |
Anwendung: | Potent autotaxin inhibitor |
CAS | 1628260-79-6 |
MW: | 588.7 D |
ab 125,00 €